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B5161

Sigma-Aldrich

Biotin 3-sulfo-N-hydroxysuccinimide ester sodium salt

≥90% (TLC), powder

Synonyme(s) :

Sulfosuccinimidyl biotin

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About This Item

Formule empirique (notation de Hill):
C14H18N3NaO8S2
Numéro CAS:
119616-38-5
Poids moléculaire :
443.43
Numéro MDL:
MFCD00078535
Code UNSPSC :
12352203
ID de substance PubChem :
24891813
Nomenclature NACRES :
NA.46

Niveau de qualité

200

Pureté

≥90% (TLC)

Forme

powder

Solubilité

H2O: 10 mg/mL
DMF: 50 mg/mL

Température de stockage

−20°C

Chaîne SMILES 

[Na].OS(=O)(=O)C1CC(=O)N(OC(=O)CCCCC2SCC3NC(=O)NC23)C1=O

InChI

1S/C14H19N3O8S2.Na.H/c18-10-5-9(27(22,23)24)13(20)17(10)25-11(19)4-2-1-3-8-12-7(6-26-8)15-14(21)16-12;;/h7-9,12H,1-6H2,(H2,15,16,21)(H,22,23,24);;

Clé InChI

NKHCQKKDLWGBRK-UHFFFAOYSA-N

Description générale

Biotin:avidin second antibody signal systems involve the conjugation of biotin to a secondary antibody. Once the secondary antibody binds to a target primary antibody in an immunochemical assay, the signal is developed by allowing avidin which has been conjugated to an enzyme or signal molecule to bind to the antibody associated biotin molecule.

Application

Water soluble biotinylation reagent. Typically coupled to primary amine in the pH range 6.5-8.5.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Warning

Classification des risques

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificats d'analyse (COA)

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P Pantano et al.
Analytical chemistry, 65(5), 623-630 (1993-03-01)
Dehydrogenase enzymes are immobilized onto carbon-fiber microelectrode surfaces via avidin-biotin technology and a covalently linked hydrophilic tether. The avidin-biotin coupling strategy allows the selectivity of the electrochemical measurement to be easily changed without reoptimizing the immobilization conditions. Optimized derivatization conditions
Wei-Bor Tsai et al.
Biomaterials, 26(16), 3141-3151 (2004-12-18)
Cell adhesion to synthetic biomaterials is a prerequisite for anchorage cell culture and tissue engineering. The current study investigated utilization of an avidin-biotin binding system in enhancing chondrocyte adhesion to tissue culture polystyrene (TCPS). Biotinylated chondrocytes adhered to avidin-coated TCPS
Wei-Bor Tsai et al.
Biotechnology and bioengineering, 98(2), 498-507 (2007-03-28)
Cell adhesion to a scaffold is a prerequisite for tissue engineering. Many studies have been focused on enhancing cell adhesion to synthetic materials that are used for scaffold fabrication. Previously, we showed that immobilization of biotin molecules to chondrocyte surfaces
Dominic Kamps et al.
Cell reports, 33(9), 108467-108467 (2020-12-03)
Local cell contraction pulses play important roles in tissue and cell morphogenesis. Here, we improve a chemo-optogenetic approach and apply it to investigate the signal network that generates these pulses. We use these measurements to derive and parameterize a system

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