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B1758

Sigma-Aldrich

Biocytin hydrochloride

≥98% (TLC), suitable for drug transporter assays

Synonyme(s) :

Nε-Biotinyl-L-lysine

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About This Item

Formule empirique (notation de Hill):
C16H28N4O4S · xHCl
Numéro CAS:
98930-70-2
Poids moléculaire :
372.48 (free base basis)
Numéro MDL:
MFCD00136057
Code UNSPSC :
12352209
ID de substance PubChem :
24891609
Nomenclature NACRES :
NA.26

product name

Biocytin hydrochloride, ≥98% (TLC)

Niveau de qualité

200

Pureté

≥98% (TLC)

Forme

powder

Technique(s)

drug transporter assay: suitable

Couleur

white to off-white

Température de stockage

−20°C

Chaîne SMILES 

Cl.NC(CCCCNC(=O)CCCCC1SCC2NC(=O)NC12)C(O)=O

InChI

1S/C16H28N4O4S.ClH/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14;/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24);1H

Clé InChI

FMGQMNFQNPUYBS-UHFFFAOYSA-N

Catégories apparentées

Application


  • Biotinylated dextran amine and biocytin hydrochloride are useful tracers for the study of retinal projections in the frog.: This paper highlights the application of biocytin hydrochloride in tracing retinal projections in amphibians. The study demonstrates the efficacy of biocytin hydrochloride in neuroanatomical mapping, facilitating research in visual system development and function (Scalia et al., 1997).


Actions biochimiques/physiologiques

Biocytin is used as a substrate to study the specificity and kinetics of biotinidase(s), to measure biotinidase deficiency and as a model compound to study various uptake mechanisms of cells and tissues.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Alessandro R Galloni et al.
eLife, 9 (2020-05-29)
Anatomical similarity across the neocortex has led to the common assumption that the circuitry is modular and performs stereotyped computations. Layer 5 pyramidal neurons (L5PNs) in particular are thought to be central to cortical computation because of their extensive arborisation
Margaret A MacNeil et al.
The Journal of comparative neurology, 506(1), 6-15 (2007-11-09)
The biocytin wide-field bipolar cell in rabbit retina has a broad axonal arbor in layer 5 of the inner plexiform layer and a wide dendritic arbor that does not contact all cones in its dendritic field. The purpose of our
Barry Wolf et al.
Molecular genetics and metabolism, 86(1-2), 44-50 (2005-09-10)
Biotinidases from various species ranging from fungi and insects to human have specific amino acids, and regions that are evolutionarily conserved. These specific amino acids and regions are further supported by their homology to a variety of amidases and nitrilases
James Peak et al.
eLife, 9 (2020-11-21)
The posterior dorsomedial striatum (pDMS) is necessary for goal-directed action; however, the role of the direct (dSPN) and indirect (iSPN) spiny projection neurons in the pDMS in such actions remains unclear. In this series of experiments, we examined the role
Aysun Pabuçcuoğlu et al.
Journal of pediatric gastroenterology and nutrition, 34(1), 59-62 (2001-12-26)
Biotinidase is the enzyme responsible for liberating the vitamin biotin from biocytin and dietary protein-bound vitamin. Individuals lacking biotinidase activity become biotin deficient. Because the liver is the major source of plasma biotinidase, chronic liver diseases can lead to decreased
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