B0560

(−)-Blebbistatin

≥98% (HPLC), solid, cell cycle inhibitor

• Synonyme(s) : 1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2.3-b]-7-methylquinolin-4-one
• Formule empirique (notation de Hill): C₁₈H₁₆N₂O₂
• Numéro CAS: 856925-71-8
• Poids moléculaire : 292.33
• Numéro MDL: MFCD08460907
• Code UNSPSC : 12352200
• ID de substance PubChem : 329773119
• Nomenclature NACRES : NA.77

Propriétés

• product name: (−)-Blebbistatin, solid, synthetic
• Niveau de qualité: 200
• Forme: solid
• Solubilité: DMSO: 5 mg/mL; chloroform: soluble(lit.); ethyl acetate: soluble(lit.); methanol: soluble(lit.); methylene chloride: soluble(lit.)
• Température de stockage: −20°C
• Chaîne SMILES: Cc1ccc2N=C3N(CC[C@@]3(O)C(=O)c2c1)c4ccccc4
• InChI: 1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m1/s1
• Clé InChI: LZAXPYOBKSJSEX-GOSISDBHSA-N

Description

Description générale

(-)-Blebbistatin, a bioactive small molecule, is a selective inhibitor of skeletal muscle and non-muscle myosin II isoforms.The mechanism of action of blebbistatin, a myosin II ATPase inhibitor, does not influence other members of the myosin superfamily, such as I, V, and X.Blebbistatin is highly light sensitive, and photobleaching can reverse its effect completely. Blebbistatin is a commonly used as excitation-contraction uncoupling agent in cardiovascular physiology. Blebbistatin controls the inhibitory effect of thrombin on intercellular Ca₂⁺ wave propagation. Blebbistatin reduces cardiac contractility by stabilizing the OFF state of the thick filament.Blebbistatin’s selectivity and affinity for multiple class II myoisin make it an attractive candidate for use in cell motility research and muscle physiology.

Application

(−)-Blebbistatin has been used to investigate the effect on cardiac contractility and effect of thrombin on actomyosin contractility

Actions biochimiques/physiologiques

(-)-Blebbistatin is a cell cycle inhibitor; selective inhibitor of non-muscle myosin II.

Caractéristiques et avantages

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves