A5835

γ-Aminobutyric acid

≥99%, suitable for ligand binding assays, BioXtra

• Synonyme(s) : 3-Carboxypropylamine, 4-Aminobutanoic acid, GABA, Piperidic acid, Piperidinic acid
• Formule linéaire : NH₂(CH₂)₃COOH
• Numéro CAS: 56-12-2
• Poids moléculaire : 103.12
• Numéro Beilstein : 906818
• Numéro CE : 200-258-6
• Numéro MDL: MFCD00008226
• Code UNSPSC : 12352106
• ID de substance PubChem : 24891025
• Nomenclature NACRES : NA.26

Propriétés

• product name: γ-Aminobutyric acid, BioXtra, ≥99%
• Gamme de produits: BioXtra
• Niveau de qualité: 200
• Pureté: ≥99%
• Forme: powder
• Technique(s): ligand binding assay: suitable
• Impuretés: <0.0005% Phosphorus (P); <0.1% Insoluble matter
• Résidus de calcination: <0.1%
• Couleur: white
• Pf: 195 °C (dec.) (lit.)
• Solubilité: H₂O: 0.5 M at 20 °C, clear, colorless
• Traces d'anions: chloride (Cl^-): <0.04%; sulfate (SO₄^2-): <0.05%
• Traces de cations: Al: <5 mg/kg; Ca: <20 mg/kg; Cu: <5 mg/kg; Fe: <5 mg/kg; K: <50 mg/kg; Mg: <50 mg/kg; NH₄⁺: <500 mg/kg; Na: <70 mg/kg; Pb: <10 mg/kg; Zn: <5 mg/kg
• Chaîne SMILES: NCCCC(O)=O
• InChI: 1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
• Clé InChI: BTCSSZJGUNDROE-UHFFFAOYSA-N
• Informations sur le gène: human ... SLC6A1(6529) , SLC6A11(6538) , SLC6A12(6539) ; rat ... Gabra1(29705) , Gabra2(29706) , Olr1750(294204) , Slc6a1(79212) , Slc6a12(50676)

Description

Description générale

γ-Aminobutyric acid (GABA) is a non-protein amino acid associated with the brain. Being synthesized in the nervous system, it is packed into synaptic vesicles. It is present naturally in green tea, soybean, germinated rice, and in some fermented foods.

Application

γ-Aminobutyric acid (GABA) has been used to treat dorsal root ganglion neurons for electrophysiological recordings studies to test its effect on neuropathic pain in rats. It has also been used to test its protective effects in an ex vivo machine perfusion system of small-for-size grafts (SFSG) injury model.

Actions biochimiques/physiologiques

γ-Aminobutyric acid (GABA) is a mammalian inhibitory neurotransmitter with multiple functions. It is crucial for the normal central nervous system (CNS) functioning. A few documented functions of GABA include its protective role in toxin-induced damage. It also elicits anti-hypertensive, anti-diabetic, anti-microbial, antioxidant, anti-allergy, anti-inflammatory, and anti-cancer effects. GABA might show beneficial effects on stress and sleep in humans. γ-Aminobutyric acid (GABA) is used to study the biological and biochemical processes mediated via the GABA receptors, GABAA and GABAB.

Major inhibitory neurotransmitter in brain; GABA_A and GABA_B receptor agonist; increases Cl⁻ conductance.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves