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MABT37

Sigma-Aldrich

Anti-Dentin sialoprotein Antibody, clone 2C12.3

clone 2C12.3, from mouse

Synonyme(s) :

Dentin sialophosphoprotein, Dentin phosphoprotein, Dentin phosphophoryn, DPP2.Dentin sialoprotein, DSP

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

2C12.3, monoclonal

Espèces réactives

mouse, rat

Technique(s)

immunohistochemistry: suitable

Isotype

IgG2bκ

Numéro d'accès NCBI

NP_036922

Numéro d'accès UniProt

Q62598

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

mouse ... Dspp(666279)

Description générale

Dentin sialophosphoprotein (DSPP) is a protein of the extracellular matrix. It belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family. DSPP is found in teeth and bone and is primarily involved in biomineralization processes in these structures. This function may be facilitated by the interaction of DSPP with multiple protein targets including DMP1, BMP2, Runx2, and NF-Y. DSPP plays a central role in dentinogenesis.

Immunogène

Pure DSP isolated rat dentin

Application

Anti-Dentin sialoprotein, clone 2C12.3 detects levels of Dentin sialoprotein proteins & has been published & validated for use in IHC.
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in rat mandibular tissue. (Baba, O., et al. (2004). Eur J Oral Sci. 112:163–170.)
Research Category
Cell Structure
Research Sub Category
Cytoskeleton

Qualité

Evaluated by Immunohistochemistry in mouse and rat teeth tissues.

Immunohistochemistry Analysis: 1:250-1,000 dilution of this antibody detected Dentin sialophosphoprotein in mouse and rat teeth tissues.

Description de la cible

68 kDa calculated. Uniprot describes 2 isoforms at 64 and 70 kDa

Forme physique

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Remarque sur l'analyse

Control
Mouse and rat teeth tissues

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Xin Gao et al.
Molecular medicine reports, 20(4), 3035-3042 (2019-08-23)
Dental epithelial‑mesenchymal signaling is crucial for tooth development, but the detailed mechanism is not fully understood. Using microarray analysis, it was revealed that the expression of osteoprotegerin, an important factor regulating bone remodeling, significantly increased after removal of the dental
Henry F Duncan et al.
Frontiers in cell and developmental biology, 10, 883266-883266 (2022-05-10)
Matrix-metalloproteinase-13 (MMP13) is important for bone formation and remodeling; however, its role in tooth development remains unknown. To investigate this, MMP13-knockout (Mmp13 -/- ) mice were used to analyze phenotypic changes in the dentin-pulp complex, mineralization-associated marker-expression, and mechanistic interactions.

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