AB5605

Anti-4-Hydroxynonenal Antibody

serum, Chemicon^®

• Synonyme(s) : 4-HNE
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: goat
• Niveau de qualité: 100
• Forme d'anticorps: serum
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Espèces réactives: human
• Fabricant/nom de marque: Chemicon^®
• Technique(s): ELISA: suitable; western blot: suitable
• Conditions d'expédition: dry ice
• Modification post-traductionnelle de la cible: unmodified

Description

Description générale

The peroxidation of membrane lipids by free radicals is a well-controlled, ongoing process that occurs during normal cell turnover and the normal aging process. There is also the uncontrolled process of free radical production and increased lipid peroxidation that is associated with hepatic injury as a consequence of exposure to halogenated hydrocarbons, excessive alcohol abuse, and acute or chronic iron overload. ′′ HNE can efficiently react with sulfhydryl groups or histidine and lysine groups of proteins to form stable HNE-protein adducts, in addition to phospholipids and nucleic acids. It is through this HNE-modification of biomolecules that HNE is thought to exert its cytotoxic effects. This multifunctional molecule may be considered as a "second toxic messenger," which disseminates and augments initial free radical events. It is believed to be largely responsible for the cytopathological effects observed during oxidative stress. High levels of 4-HNE have been detected in a large number of disease states, indicating some involvement of this aldehyde in their pathogenesis. Some of the prominent pathobiochemical effects of 4-HNE are its stimulation of fibrogenesis and inflammation. This indicates a potential contribution to the pathogenesis of several chronic diseases, the progression of which is supported by inflammatory reactions and characterized by fibrosis. 4-HNE may also play a role in carcinogenesis due to its ability to modulate cell proliferation through interference with the activity of cyclins and protein kinases and inhibiting the apoptotic response.

Spécificité

Specific for 4-Hydroxynonenal (4-HNE).

The HNE moiety recognized by this AB5605 antibody is a biochemical modification independent of species. The anit-4-HNE antibody should have wide species reactivity accordingly.

Immunogène

4-HNE.

Application

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Domaine de recherche
Neurosciences

Sous-domaine de recherche
Stress oxydatif

Western blotting : ′
ELISA : >

Forme physique

Goat antiserum. Liquid with 0.1% sodium azide

Stockage et stabilité

Conserver à -20 °C sous forme non diluée pendant 6 mois maximum à partir de la date de réception. Éviter les congélation/décongélation répétées. Ne pas conserver dans un congélateur à dégivrage automatique.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Sauf indication contraire dans notre catalogue ou toute autre documentation associée au(x) produit(s), nos produits sont uniquement destinés à la recherche et ne sauraient être utilisés à d'autres fins, ce qui inclut, sans s'y limiter, les utilisations commerciales non autorisées, les utilisations diagnostiques in vitro, les utilisations thérapeutiques ex vivo ou in vivo, ou tout type de consommation ou d'application chez l'être humain ou chez l'animal.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable