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Merck
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551476

Sigma-Aldrich

Q-VD-OPh, Non-O-methylated

≥90% (HPLC), liquid, Caspase inhibitor, Calbiochem®

Synonyme(s) :

InSolution Q-VD-OPh, Non-O-methylated, N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone

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About This Item

Formule empirique (notation de Hill):
C26H25F2N3O6
Poids moléculaire :
513.49
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

product name

Q-VD-OPh, Non-O-methylated, InSolution, ≥90%, irreversible broad-spectrum inhibitor of caspases

Niveau de qualité

100

Pureté

≥90% (HPLC)

Forme

liquid

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze
desiccated (hygroscopic)
protect from light

Conditions d'expédition

wet ice

Température de stockage

−20°C

Description générale

A cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.

Actions biochimiques/physiologiques

Cell permeable: yes
Primary Target
caspase-1
Product does not compete with ATP.
Reversible: no
Target IC50: 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Irritant (B)

Séquence

Q-Val-Asp-CH₂-OPh

Forme physique

Supplied as a 10 mM (1 mg/195 µl) solution in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Autres remarques

Braun, J.S., et al. 2007. Exp. Neurol.206, 183.
Caserta, T.M., et al. 2003. Apoptosis8, 345.
Rebbaa, A., et al. 2003. Oncogene22, 2805.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

188.6 °F - closed cup - (Dimethylsulfoxide)

Point d'éclair (°C)

87 °C - closed cup - (Dimethylsulfoxide)

Certificats d'analyse (COA)

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Sara H Small et al.
Science signaling, 14(714), eaba2611-eaba2611 (2021-12-22)
Cytokine production is a critical component of cell-extrinsic responses to DNA damage and cellular senescence. Here, we demonstrated that expression of the gene encoding interleukin-19 (IL-19) was enhanced by DNA damage through pathways mediated by c-Jun amino-terminal kinase (JNK) and
Joshua D Bryant et al.
Current protocols, 2(2), e372-e372 (2022-02-18)
Mitochondria have emerged as key drivers of mammalian innate immune responses, functioning as signaling hubs to trigger inflammation and orchestrating metabolic switches required for phagocyte activation. Mitochondria also contain damage-associated molecular patterns (DAMPs), molecules that share similarity with pathogen-associated molecular
Javier Chicote et al.
Frontiers in pharmacology, 11, 580343-580343 (2020-11-13)
Macroautophagy (hereafter autophagy) is a multistep intracellular catabolic process with pleiotropic implications in cell fate. Attending to its activation, autophagy can be classified into inducible or constitutive. Constitutive, or basal autophagy, unfolds under nutrient-replete conditions to maintain the cellular homeostasis.
Yuanjiu Lei et al.
Cell, 186(14), 3013-3032 (2023-06-24)
Mitochondrial DNA (mtDNA) is a potent agonist of the innate immune system; however, the exact immunostimulatory features of mtDNA and the kinetics of detection by cytosolic nucleic acid sensors remain poorly defined. Here, we show that mitochondrial genome instability promotes

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