PZ0280

CP-456773 sodium salt

≥98% (HPLC), powder, IL-1β secretion inhibitor

• Synonyme(s) : CRID3, Cytokine release inhibitory drug 3, MCC950, N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt
• Formule empirique (notation de Hill): C₂₀H₂₃N₂NaO₅S
• Numéro CAS: 256373-96-3
• Poids moléculaire : 426.46
• Code UNSPSC : 51111800
• ID de substance PubChem : 329823808
• Nomenclature NACRES : NA.77

Propriétés

• product name: CP-456773 sodium salt, ≥98% (HPLC)
• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: H₂O: 20 mg/mL, clear
• Température de stockage: room temp
• Chaîne SMILES: CC(O)(C)C1=COC(S([N-]C(NC2=C(CCC3)C3=CC4=C2CCC4)=O)(=O)=O)=C1.[Na+]
• InChI: 1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1
• Clé InChI: LFQQNXFKPNZRFT-UHFFFAOYSA-M

Description

Application

CP-456773 sodium salt has been used :

• In in vivo experiments to study the neuroprotective action of ketogenic diet.
• To study the effect of inhibition of NLRP3 (nod-like receptor protein 3) inflammasome activity on tumor progression in mouse models.
• To study the cholesterol crystal-mediated IL-1b (interleukin-1b) response in placental explants.

Actions biochimiques/physiologiques

CP-456773 is known to inhibit the release of other proinflammatory cytokines such as IL-1α and IL-18. It is also referred to as MCC950.

CP-456773 sodium salt (CRID3) was found to act as a cytokine release inhibitory drug and inhibitor of the NLRP3 inflammasome. CP-456773 sodium salt inhibits interleukin 1β (IL-1β) secretion and caspase 1 processing.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable