390238

Camptothecin

from Camptotheca acuminata, ≥95% (HPLC), powder, DNA topoisomerase I inhibitor, Calbiochem^®

• Synonyme(s) : Camptothecin, 10-Hydroxy-, Camptotheca acuminata, 10-Hydroxycamptothecin, HCPT
• Formule empirique (notation de Hill): C₂₀H₁₆N₂O₅
• Numéro CAS: 64439-81-2
• Poids moléculaire : 364.35
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• product name: Camptothecin, 10-Hydroxy-, Camptotheca acuminata, A cell-permeable powerful DNA topoisomerase I inhibitor.
• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: powder
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: pale yellow
• Solubilité: DMSO: 5 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3
• Clé InChI: HAWSQZCWOQZXHI-UHFFFAOYSA-N

Description

Description générale

A cell-permeable powerful DNA topoisomerase I inhibitor. Reduces DNA synthesis in vitro in murine hepatoma cells. Has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.

A cell-permeable, powerful DNA topoisomerase I inhibitor. Reduces DNA synthesis in vitro in murine hepatoma cells. Inhibits the proliferation of hepatoma HepG2, Bcl-7402 and Bcl-7404 cells in a dose-dependent manner. Has selective inhibitory effect on the phosphorylation of histones H1 and H3, but is less effective on other histones.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
DNA topoisomerase I

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Zhang, X.W., et al. 1999. Anticancer Drugs.10, 569.
Ling, Y.H., et al. 1993. Anticancer Res. 13, 1613.
Wani, M.C., and Wall, M.E. 1969. J. Org.Chem.34, 1364.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H301,H340
• Conseils de prudence: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral - Muta. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable