360512

Glycocholic Acid, Sodium Salt

Formed by the conjugation of cholic acid with glycine. Aggregation number: 2.1.

• Synonyme(s) : Glycocholic Acid, Sodium Salt, GAS, Sodium cholylglycinate
• Numéro CAS: 863-57-0
• Code UNSPSC : 12352106
• Nomenclature NACRES : NA.21

Propriétés

• Niveau de qualité: 100
• Pureté: 100.1% dry basis (titration)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Nombre d'agrégation: 2.1
• Couleur: white to off-white
• pKa: 3.8
• CMC: 7.1 mM
• Solubilité: water: 200 mg/mL; ethanol: soluble
• Conditions d'expédition: ambient
• Température de stockage: 15-25°C
• InChI: 1S/C26H43NO6.Na/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29;/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33);/q;+1/p-1
• Clé InChI: OABYVIYXWMZFFJ-UHFFFAOYSA-M

Description

Description générale

Formed by the conjugation of cholic acid with glycine. Aggregation number: 2.1.

Glycocholic acid (GCA) is a crystalline secondary bile acid. It is a conjugate of cholic acid and glycine. The microbiota produces GCA in the small intestine by the catalysis of enzymes. Glycocholic Acid, Sodium Salt, an anionic surfactant with a steroidal backbone is soluble in water.Formed by the conjugation of cholic acid with glycine (aggregation number: 2.1; CMC: 7.1 mM; pK_a: 3.8).

Application

Glycocholic Acid, Sodium Salt- is suitable for use:

• as a component in the sodium phosphate/NaCl (phosphate buffer saline-PBS) buffer to prepare protein samples
• in the preparation of fluorescently labeled mixed micelles to investigate the uptake by and transport through Caco-2 cells of two mixed micelle formulations of vitamin K
• to prepare mixed micelle solutions to encapsulate a lipid-soluble drug (vitamin K₁) to analyze its influence on the quality and stability of the mixed micelle systems

Actions biochimiques/physiologiques

Glycocholic acid (GCA) is involved in the emulsification of fats. Glycocholic acid sodium (GAS) salt is one of the important cholic acid salts in the pharmaceutical industry used to prepare mixed micelles (MMs).

Avertissement

Toxicity: Standard Handling (A)

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable