54802

1-Hydroxybenzotriazole hydrate

≥97.0% dry basis (T), for peptide synthesis

• Synonyme(s) : HOBt Hydrate
• Formule empirique (notation de Hill): C₆H₅N₃O · xH₂O
• Numéro CAS: 123333-53-9
• Poids moléculaire : 135.12 (anhydrous basis)
• Numéro Beilstein : 4515
• Numéro CE : 219-989-7
• Code UNSPSC : 12352000
• ID de substance PubChem : 57651485
• Nomenclature NACRES : NA.22

Propriétés

• product name: 1-Hydroxybenzotriazole hydrate, ≥97.0% dry basis (T)
• Niveau de qualité: 200
• Pureté: ≥97.0% dry basis (T)
• Forme: solid
• Composition: water, ~12%
• Capacité de réaction: reaction type: Addition Reactions
• Pf: 155-158 °C (lit.)
• Solubilité: DMF: 0.1 g/mL, clear
• Application(s): peptide synthesis
• Chaîne SMILES: [H]O[H].On1nnc2ccccc12
• InChI: 1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2
• Clé InChI: PJUPKRYGDFTMTM-UHFFFAOYSA-N

Description

Description générale

1-Hydroxybenzotriazole is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids. It is also used as a racemization suppressor during peptide synthesis.

Application

1-Hydroxybenzotriazole hydrate can be used as a condensation reagent to prepare:

• Poly-γ-glutamic acid methyl ester from a dimer of γ-glutamic acid.
• Oxadiazoles via cyclo condensation of amidoximes with trifluoroacetic anhydride or benzoic acid derivatives.

Autres remarques

Widely used additive to decrease racemization in the carbodiimide peptide coupling; Racemization-free condensation of peptide fragments

Informations sur la sécurité

• Pictogrammes: GHS02,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H207,H319,H412
• Conseils de prudence: P210 - P212 - P230 - P233 - P280 - P370 + P380 + P375 - P501
• Classification des risques: Aquatic Chronic 3 - Desen. Expl. 2 - Eye Irrit. 2
• Code de la classe de stockage: 4.1A - Other explosive hazardous materials
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 314.6 °F
• Point d'éclair (°C): 157 °C