T2455

T3MG

• Synonyme(s) : (±)-threo-3-Methylglutamic acid, 3MG, threo-3-Methylglutamate
• Formule empirique (notation de Hill): C₆H₁₁NO₄
• Numéro CAS: 63088-04-0
• Poids moléculaire : 161.16
• Numéro MDL: MFCD09836097
• Code UNSPSC : 12352200
• ID de substance PubChem : 329826708
• Nomenclature NACRES : NA.77

Propriétés

• Forme: powder
• Niveau de qualité: 100
• Couleur: white to off-white
• Solubilité: H₂O: >1.5 mg/dL
• Adéquation: suitable for TLC (single spot)
• Température de stockage: room temp
• Chaîne SMILES: C[C@@H](CC(O)=O)[C@@H](N)C(O)=O
• InChI: 1S/C6H11NO4/c1-3(2-4(8)9)5(7)6(10)11/h3,5H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,5+/m0/s1
• Clé InChI: FHJNAFIJPFGZRI-WVZVXSGGSA-N

Description

Actions biochimiques/physiologiques

T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4.

T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EAAT function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels.

Caractéristiques et avantages

This compound is featured on the Excitatory Amino Acid Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Notes préparatoires

T3MG dissolves in water at a concentration that is greater than 1.5 mg/ml.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable