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B4560

Sigma-Aldrich

6-Bnz-cAMP sodium salt

≥98% (HPLC)

Synonyme(s) :

N6-Benzoyladenosine-3′,5′-cyclic monophosphate sodium salt

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About This Item

Formule empirique (notation de Hill):
C17H15N5O7PNa
Numéro CAS:
30275-80-0
Poids moléculaire :
455.29
Numéro MDL:
MFCD01074967
Code UNSPSC :
12352200
ID de substance PubChem :
24724421
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Conditionnement

vial of 10 μmol

Conditions de stockage

desiccated

Couleur

white

Solubilité

H2O: freely soluble

Conditions d'expédition

dry ice

Température de stockage

−70°C

Chaîne SMILES 

[Na+].O[C@@H]1[C@@H]2OP([O-])(=O)OC[C@H]2O[C@H]1n3cnc4c(NC(=O)c5ccccc5)ncnc34

InChI

1S/C17H16N5O7P.Na/c23-12-13-10(6-27-30(25,26)29-13)28-17(12)22-8-20-11-14(18-7-19-15(11)22)21-16(24)9-4-2-1-3-5-9;/h1-5,7-8,10,12-13,17,23H,6H2,(H,25,26)(H,18,19,21,24);/q;+1/p-1/t10-,12-,13-,17-;/m1./s1

Clé InChI

SPYGSKQRPXISIB-FKVBDRBCSA-M

Actions biochimiques/physiologiques

6-Bnz-cAMP is a membrane permeable and selective cAMP-dependent protein kinase (PKA) activator. For preferential stimulation of cAK type I, a combination with the site B selective analog 8-HA-cAMP or 8-AHA-cAMP can be used.

Caractéristiques et avantages

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

R A Steinberg et al.
The Journal of biological chemistry, 271(44), 27630-27636 (1996-11-01)
The guanidinium groups of conserved arginines in the two intrachain cAMP-binding sites of regulatory (R) subunit of cAMP-dependent protein kinase have been implicated in the allosteric interactions by which cAMP binding leads to kinase activation. We have investigated the functional
W Eskild et al.
Biochemical and biophysical research communications, 152(3), 1504-1510 (1988-05-16)
The levels of mRNA for cellular retinol binding protein (CRBP) were studied in primary rat Sertoli cell cultures treated with cAMP analogues and retinol. In the presence of cyclic AMP analogues a dose- and time-dependent reduction (70-90%) of the levels
R A Prosser et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(17), 6812-6815 (1989-09-01)
The suprachiasmatic nuclei (SCN) of mammals contain a circadian clock that synchronizes behavioral and physiological rhythms to the daily cycle of light and darkness. We have been probing the biochemical substrates of this endogenous pacemaker by examining the ability of
D O Quissell et al.
Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists, 4(3-4), 443-448 (1993-01-01)
A series of cAMP analogs that have different specificities for the two different binding sites on the regulatory subunit of type I and type II cAMP-dependent protein kinase (PKA) were used to determine whether selective activation of type I or
B M Hokland et al.
The Journal of biological chemistry, 268(34), 25343-25349 (1993-12-05)
The interaction of high density lipoprotein with its putative receptor stimulates translocation and efflux of intracellular sterols by a process involving activation of protein kinase C. This study shows that activation of cAMP-dependent protein kinase also stimulates efflux of intracellular
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