SML0846

Anagrelide hydrochloride

≥98% (HPLC)

• Synonyme(s) : 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-2(3H)-one hydrochloride
• Formule empirique (notation de Hill): C₁₀H₇Cl₂N₃O · HCl
• Numéro CAS: 58579-51-4
• Poids moléculaire : 292.55
• Code UNSPSC : 41106305
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: DMSO: 1 mg/mL, clear (warmed)
• Température de stockage: 2-8°C
• InChI: 1S/C10H7Cl2N3O.ClH/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7;/h1-2H,3-4H2,(H,13,14,16);1H
• Clé InChI: TVWRQCIPWUCNMI-UHFFFAOYSA-N

Description

Description générale

Download the CofA, SDS and IFU specific to your product lot and format
Fab fragments from polyclonal anti-fluorescein antibodies, conjugated to alkaline phosphatase.
After immunization with fluorescein, the sheep IgG was purified by ion exchange chromatography and the specific IgG was isolated by immunosorption. The Fab fragments obtained by papain digestion were purified by gel filtration, conjugated with alkaline phosphatase, and stabilized in 50 mM triethanolamine buffer, 3 M NaCl, 1 mM MgCl₂, 0.1 mM ZnCl₂, 1% bovine serum albumin (w/v), pH 7.6.
Clone: polyclonal
Ig class: sheep IgG, Fab fragments

Anagrelide belongs to the imidazo[2,1-b]quinazolin-2-one series of compounds.

Actions biochimiques/physiologiques

Anagrelide is a phosphodiesterase inhibitor with antiplatelet activity (IC₅₀ = 36 nM for inhibition of phosphodiesterase-III). Anagrelide inhibits the maturation of megakaryocytes into platelets, reducing both megakaryocyte hyperproliferation and differentiation. As a drug, anagrelide is antithrombocythemic used for the treatment of overproduction of blood platelets.

Anagrelide is a phosphodiesterase inhibitor with antiplatelet activity.

In human and animals, anagrelide has an inhibitory effect on platelet aggregation. Small doses of anagrelide can generate thrombocytopenia. Anagrelide is not advised during pregnancy. It is effectively used in the treatment of essential thrombocytosis.

Caractéristiques et avantages

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Warning
• Mentions de danger: H351,H361d,H413
• Conseils de prudence: P202 - P273 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Aquatic Chronic 4 - Carc. 2 - Repr. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable