SML0038

Fluvastatin sodium hydrate

≥98% (HPLC)

• Synonyme(s) : (±)-(3R^*,5S^*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt hydrate
• Formule empirique (notation de Hill) : C₂₄H₂₅FNO₄ · Na · xH₂O
• Numéro CAS: 93957-55-2
• Poids moléculaire : 433.45 (anhydrous basis)
• Numéro MDL: MFCD20488050
• Code UNSPSC : 12352204
• ID de substance PubChem : 329825108
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to tan
• Solubilité: H₂O: ≥9 mg/mL
• Auteur: Novartis
• Température de stockage: 2-8°C
• Chaîne SMILES: O.[Na+].CC(C)n1c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c3ccccc13
• InChI: 1S/C24H26FNO4.Na.H2O/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);;1H2/q;+1;/p-1/b12-11+;;/t18-,19-;;/m1../s1
• Clé InChI: KKEMYLLTGGQWCE-PMRANXHDSA-M

Description

Application

Fluvastatin sodium hydrate has been used:

• to examine its effect on β -glucan-induced training on immunity[1]
• to investigate the effect of statins on the number of uncoupling protein 1 (UCP1)⁺ cells[2]
• to determine its effect on insulin degrading enzyme (IDE) secretion from astrocytes[3]
• to treat and study its effect on human umbilical vein endothelial cells (HUVECs) in vitro[4]

Fluvastatin sodium hydrate has been used:

• to test its anti-hepatitis C virus (HCV) activity[5]
• as a cholesterol inhibitor[6]
• to study its effects on β-glucan-induced monocyte immune training[1]

Actions biochimiques/physiologiques

Fluvastatin has antifungal activity.[7]

Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.

Caractéristiques et avantages

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable