K2389

Kainic acid monohydrate

≥98% (HPLC), from Digenea simplex

• Synonyme(s) : 2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine
• Formule empirique (notation de Hill): C₁₀H₁₅NO₄ · H₂O
• Numéro CAS: 58002-62-3
• Poids moléculaire : 231.25
• Numéro MDL: MFCD00150833
• Code UNSPSC : 12352106
• ID de substance PubChem : 24724520
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: Digenea simplex
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white
• Solubilité: H₂O: >10 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: O.CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
• InChI: 1S/C10H15NO4.H2O/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13;/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15);1H2/t6-,7+,9-;/m0./s1
• Clé InChI: FZNZRJRSYLQHLT-SLGZUKMRSA-N

Description

Application

Kainic acid monohydrate has been used:

• As a convulsant to induce epileptogenesis and epilepsy in mice.
• To stimulate in vitro excitotoxic trauma in spiral ganglion neurons on inner hair cells.
• To induce seizures in rat model.
• To induce status epilepticus in adult male Wistar rats.

Actions biochimiques/physiologiques

Ionotropic glutamate receptors form ion channels, and conduct Na⁺ and K⁺ fluxes. The receptors possess an agonist binding site and it encounters a conformational change upon agonist binding to it. Kainate gated channels participate in glutamate-induced excitatory postsynaptic neuronal potential.

Kainic acid monohydrate is an agonist at the kainate class of ionotropic glutamate receptors, which induces seizures and neurodegeneration in vivo and is used to induce experimental epilepsy in rodents and study the mechanisms of excitation-induced neuronal apoptosis.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)