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F9428

Sigma-Aldrich

Fluticasone propionate

≥98% (HPLC), powder

Synonyme(s) :

(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester

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About This Item

Formule empirique (notation de Hill):
C25H31F3O5S
Numéro CAS:
80474-14-2
Poids moléculaire :
500.57
Numéro MDL:
MFCD00866007
Code UNSPSC :
12352200
ID de substance PubChem :
329799785
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white

Solubilité

DMSO: ≥10 mg/mL

Auteur

GlaxoSmithKline

Chaîne SMILES 

CCC(=O)O[C@@]1([C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)SCF

InChI

1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1

Clé InChI

WMWTYOKRWGGJOA-CENSZEJFSA-N

Informations sur le gène

human ... NR3C1(2908)

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Description générale

Fluticasone blocks mast cells, eosinophils, lymphocytes, neutrophils and macrophages.

Actions biochimiques/physiologiques

Fluticasone propionate is a second generation glucocorticoid. Used as an anti-inflammatory agent for asthma. Shown to enhance eosinophil apoptosis in a concentration-dependent manner via the glucocorticoid receptor.

Caractéristiques et avantages

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Warning

Mentions de danger

H361f,H373

Classification des risques

Repr. 2 - STOT RE 2

Organes cibles

Endocrine system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Small Animal Clinical Pharmacology (2008)
David Price et al.
The Journal of allergy and clinical immunology, 131(3), 763-771 (2013-02-06)
Many asthmatic patients are unable to quit cigarettes; therefore information is needed on treatment options for smokers. This study evaluates 10 mg/d montelukast and 250 μg of fluticasone propionate twice daily, each compared with placebo, in patients with self-reported active smoking
Kate McKeage
Drugs, 73(2), 195-206 (2013-02-12)
The corticosteroid fluticasone propionate (fluticasone) and the long-acting β₂-adrenoceptor agonist formoterol fumarate (formoterol) have been combined in a single, pressurized, metered-dose, aerosol inhaler for the maintenance treatment of patients aged ≥12 years with persistent asthma. This article reviews the clinical
Melanie Manetsch et al.
PloS one, 8(3), e59635-e59635 (2013-03-28)
Mitogen-activated protein kinase phosphatase 1 (MKP-1) represses MAPK-driven signalling and plays an important anti-inflammatory role in asthma and airway remodelling. Although MKP-1 is corticosteroid-responsive and increased by cAMP-mediated signalling, the upregulation of this critical anti-inflammatory protein by long-acting β2-agonists and
Chris Stockmann et al.
The Journal of pediatrics, 162(6), 1222-1227 (2013-01-08)
To determine the relationship between allelic variations in genes involved in fluticasone propionate (FP) metabolism and asthma control among children with asthma managed with inhaled FP. The relationship between variability in asthma control scores and genetic variation in drug metabolism
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