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A4544

Sigma-Aldrich

Acide L-ascorbique

suitable for cell culture, suitable for plant cell culture, ≥98%

Synonyme(s) :

Acide L-thréoascorbique, Facteur anti-scorbut, Vitamine C

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25 G
40,00 €
100 G
92,80 €
500 G
218,00 €

40,00 €

Date d'expédition estimée le31 mars 2025

Devis pour commande en gros
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25 G
40,00 €
100 G
92,80 €
500 G
218,00 €

About This Item

Formule empirique (notation de Hill):
C6H8O6
Numéro CAS:
50-81-7
Poids moléculaire :
176.12
Beilstein:
84272
Numéro CE :
200-066-2
Numéro MDL:
MFCD00064328
Code UNSPSC :
12352201
ID de substance PubChem :
24890875
Nomenclature NACRES :
NA.21

40,00 €

Date d'expédition estimée le31 mars 2025

Devis pour commande en gros

Niveau de qualité

200

Essai

≥98%

Forme

powder

Poids mol.

Mw 176.12 g/mol

Technique(s)

cell culture | mammalian: suitable
cell culture | plant: suitable

Couleur

white to light yellow

pH

1.0-2.5 (25 °C, 176 g/L in water)

Pf

190-194 °C (dec.)

Solubilité

water: soluble 50 mg/mL

Chaîne SMILES 

OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O

InChI

1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

Clé InChI

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

Informations sur le gène

human ... SLC23A2(9962)

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Description générale

L-ascorbic acid also called vitamin C, is a water soluble vitamin and acts as a reducing agent for various biochemical reactions. Ascorbic acid plays a key role in the production of collagen. Ascorbic acid is essential for neurodevelopment, neurotransmitter synthesis and modulates neuronal synapsis.[1] Dietary inadequacy of vitamin C has negative impact on cognition.[2]

Application

L-ascorbic acid has been used as an ingredient in the basal medium for bovine mammary epithelial cells[3] and oocyte-granulosa cell complexes.[4] It has been used as a supplement in the osteogenic medium for osteogenic differentiation.[5][6]

Actions biochimiques/physiologiques

Ascorbic Acid, also known as Vitamin C, is a six-carbon lactone produced by plants and some animal species but not by humans and other primates. Ascorbic acid functions as an enzymatic cofactor for multiple enzymes, serving as an electron donor for monooxygenases and dioxygenases. Ascorbic acid also functions as a powerful antioxidant, particularly in regards to reactive oxygen species.

Autres remarques

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
WXBF4565V
0000354913
0000354914
0000367491
0000367489

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Multipotency and cardiomyogenic potential of human adipose-derived stem cells from epicardium, pericardium, and omentum
Wystrychowski W, et al.
Stem Cell Research & Therapy, 7(1), 84-84 (2016)
The effect of mesenchymal stromal cells on the osseoinduction of impaction grafts
Korda M, et al.
Tissue Engineering: Part A, 16(2), 675-683 (2009)
Mitochondrial dysfunction of in vitro grown rabbit oocytes results in preimplantation embryo arrest after activation
Kanaya H, et al.
Journal of Reproduction and Development, 53(3), 631-637 (2007)
Vitamin C status and cognitive function: A systematic review
Travica N, et al.
Nutrients, 9(9), 960-960 (2017)
Does vitamin C deficiency affect cognitive development and function?
Hansen SN, et al.
Nutrients, 6(9), 3818-3846 (2014)
Afficher tous les articles scientifiques apparentés

Articles

Ascorbate in Cell Culture

Importance and uses of ascorbate in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures

Questions

1–3 sur 3 questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 réponse

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 réponse

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. Can we store vitamin C solution (25mM) at -20 degree? In case for how many time it can be stored?

    1 réponse

    1. The solution stability of this compound has not been determined, however it is subject to degradation when exposted to oxygen or alkaline pH conditions. As a general rule, avoid repeated freeze/thaw cycles. The publication below indicates that the material is stable when stored frozen in RPMI-1640 at -20°C.
      https://pubmed.ncbi.nlm.nih.gov/1698293/

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