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Y0000027

Succinate de sumatriptan

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

GR-43175, Succinate de 3-[2-(diméthylamino)éthyl]- N-méthyl-1H-indole-5-méthanesulfonamide

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About This Item

Formule empirique (notation de Hill):
C14H21N3O2S · C4H6O4
Numéro CAS:
103628-48-4
Poids moléculaire :
413.49
Numéro MDL:
MFCD00902856
Code UNSPSC :
41116107
ID de substance PubChem :
329830819
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

sumatriptan

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

−20°C

Chaîne SMILES 

OC(=O)CCC(O)=O.CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1

InChI

1S/C14H21N3O2S.C4H6O4/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3;5-3(6)1-2-4(7)8/h4-5,8-9,15-16H,6-7,10H2,1-3H3;1-2H2,(H,5,6)(H,7,8)

Clé InChI

PORMUFZNYQJOEI-UHFFFAOYSA-N

Informations sur le gène

human ... HTR1B(3351) , HTR1D(3352)

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Sumatriptan for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Le succinate de sumatriptan est un agoniste des récepteurs de la sérotonine 5-HT1.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

1642201

Succinate de sumatriptan, United States Pharmacopeia (USP) Reference Standard

1642212

Sumatriptan Succinate Related Compound A, United States Pharmacopeia (USP) Reference Standard

Y0000026

Sumatriptan impurity mixture, European Pharmacopoeia (EP) Reference Standard

Y0000022

Succinate de sumatriptan, European Pharmacopoeia (EP) Reference Standard

1642154

Sumatriptan, United States Pharmacopeia (USP) Reference Standard

1642256

Sumatriptan succinate Related Impurities, United States Pharmacopeia (USP) Reference Standard

1642223

Composé C apparenté au succinate de sumatriptan, United States Pharmacopeia (USP) Reference Standard

BP950

Succinate de sumatriptan, British Pharmacopoeia (BP) Reference Standard

PHR2579

Sumatriptan, pharmaceutical secondary standard, certified reference material

PHR2914

Sumatriptan Succinate Related Compound C, certified reference material, pharmaceutical secondary standard

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Warning

Mentions de danger

H361d,H412

Classification des risques

Aquatic Chronic 3 - Repr. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Yasunari Sakamoto et al.
World journal of gastroenterology, 18(26), 3415-3419 (2012-07-19)
To determine the effect of oral sumatriptan on gastric emptying using a continuous ¹³C breath test (BreathID system). Ten healthy male volunteers participated in this randomized, 2-way crossover study. The subjects fasted overnight and were randomly assigned to receive a
Luigi Alberto Pini et al.
The journal of headache and pain, 13(8), 669-675 (2012-10-12)
In this study, we compared the efficacy and tolerability of the combination of paracetamol 1,000 mg + caffeine 130 mg (PCF) with sumatriptan 50 mg (SUM) in migraine attacks. This was a multi-center randomized double-blind, double-dummy, cross-over controlled trial. The
Y Sekino et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 24(12), 1083-e564-1083-e564 (2012-08-14)
Oral sumatriptan administration has been reported to delay gastric emptying after liquid meals. The aim of this study was to determine whether delayed gastric emptying is caused by enhanced gastric accommodation, impaired antral contractions, or both using ultrasonography. Ten healthy
Shree G Sharma et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 61(2), 326-329 (2012-12-05)
Renal cortical infarction is a rare cause of acute kidney injury that results from inadequate blood flow to the kidney, most commonly as a consequence of thrombotic or embolic occlusion of the renal artery or profound hypoperfusion. We report the
M J Cózar-Bernal et al.
Journal of pharmaceutical and biomedical analysis, 72, 251-260 (2012-10-16)
In this paper, a novel, precise, specific, accurate and rapid reversed-phase high performance liquid chromatographic method was developed, optimized and validated for determining sumatriptan succinate in niosomes with the best chromatographic peak resolution, reduced run time and low cost of
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