34865

Tetrahydrofuran

≥99.9%, suitable for HPLC, inhibitor-free

• Synonym(s): THF, Butylene oxide, Oxolane, Tetramethylene oxide
• Empirical Formula (Hill Notation): C₄H₈O
• CAS Number: 109-99-9
• Molecular Weight: 72.11
• Beilstein: 102391
• EC Number: 203-726-8
• MDL number: MFCD00005356
• UNSPSC Code: 41116105
• PubChem Substance ID: 329755073
• NACRES: NA.21
• Assay: ≥99.9%
• technique(s): HPLC: suitable
• application(s): food and beverages
• bp: 65-67 °C (lit.)
• vapor pressure: 114 mmHg ( 15 °C); 143 mmHg ( 20 °C)

Properties

• Product Name: Tetrahydrofuran, inhibitor-free, suitable for HPLC, ≥99.9%
• vapor density: 2.5 (vs air)
• Quality Level: 100
• vapor pressure: 114 mmHg ( 15 °C); 143 mmHg ( 20 °C)
• Assay: ≥99.9%
• form: liquid
• autoignition temp.: 610 °F
• expl. lim.: 1.8-11.8 %
• technique(s): HPLC: suitable
• impurities: ≤0.0005% non-volatile matter; ≤0.002% free acid (as CH₃COOH); ≤0.05% peroxides (as H₂O₂); ≤0.05% water (Karl Fischer)
• evapn. residue: ≤0.0005%
• color: APHA: ≤10
• refractive index: n20/D 1.407 (lit.)
• pH: ~7
• bp: 65-67 °C (lit.)
• mp: −108 °C (lit.)
• density: 0.889 g/mL at 25 °C (lit.)
• absorption: ≤0.0044 at 315 nm; ≤0.005 at 350 nm; ≤0.005 at 400 nm; ≤0.02 at 300 nm; ≤0.046 at 275 nm; ≤0.18 at 250 nm; ≤0.26 at 245 nm; ≤1.0 at 212 nm
• UV absorption: λ: 245 nm A_max: ≤0.26; λ: 275 nm A_max: ≤0.046; λ: 315 μm A_max: ≤0.0044
• suitability: complies for IR spectroscopy
• application(s): food and beverages
• SMILES string: C1CCOC1
• InChI: 1S/C4H8O/c1-2-4-5-3-1/h1-4H2
• InChI key: WYURNTSHIVDZCO-UHFFFAOYSA-N

Description

General description

Tetrahydrofuran (THF) is widely employed as a solvent. It constitutes the key fragment of various natural products (polyether antibiotics).[1] THF forms a double hydrate with hydrogen sulfide. Crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies.[2] Butane-1,4-diol is formed as an intermediate during the synthesis of THF.[3] Hot THF is useful for the dissolution of polyvinylidene chloride (PVDV).[4]

Application

Suitable for HPLC, spectrophotometry, environmental testing

Tetrahydrofuran may be used for the dissolution of poly-ε-caprolactone (PCL) and 1,3-diaminopentane, during the preparation of poly-ε-caprolactone (PCL)-hydroxyapatite (HA) scaffolds[5] and acrylate-terminated poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) (C32)- 1,3-diaminopentane (117) polymer,[6] respectively.

Other Notes

Important notice

• The article number 34865-4X2.5L will be discontinued. Please order the single bottle 34865-2.5L which is physically identical with the same exact specifications.
• The article number 34865-6X1L will be discontinued. Please order the single bottle 34865-1L which is physically identical with the same exact specifications.

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Safety Information

• Pictograms: GHS02,GHS08,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H302,H319,H335,H336,H351
• Precautionary Statements: P202 - P210 - P233 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• Target Organs: Central nervous system, Respiratory system
• Supplementary Hazards: EUH019
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): -6.2 °F - closed cup
• Flash Point(C): -21.2 °C - closed cup