Z3003

Zardaverine

Name: Zardaverine
Brand: SIGMA
Price: 182 EUR

powder, ≥98% (HPLC)

Sinónimos:

6-(4-Difluoromethoxy-3-methoxyphenyl)-3(2H)-pyridazinone

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5 MG

182,00 €

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Fórmula empírica (notación de Hill):

C₁₂H₁₀F₂N₂O₃

Número CAS:

101975-10-4

Peso molecular:

268.22

UNSPSC Code:

12352202

PubChem Substance ID:

24278784

NACRES:

NA.77

MDL number:

MFCD00867059

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Nombre del producto

Zardaverine,

SMILES string

COc1cc(ccc1OC(F)F)C2=NNC(=O)C=C2

InChI key

HJMQDJPMQIHLPB-UHFFFAOYSA-N

InChI

1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17)

Quality Level

200

Gene Information

human ... PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE7A(5150)
rat ... Pde2a(81743), Pde4a(25638)

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Este artículo	C7971	SRP0262	SRP0429
Sigma-Aldrich Z3003 Zardaverine	Sigma-Aldrich C7971 Cilostamide	Sigma-Aldrich SRP0262 PDE4A1A Active human	Sigma-Aldrich SRP0429 PDE4A10 active human
Gene Information human ... PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE7A(5150) rat ... Pde2a(81743), Pde4a(25638)	Gene Information human ... PDE3A(5139), PDE3B(5140), PDE5A(8654), PDE7A(5150) rat ... Pde2a(81743), Pde4a(25638)	Gene Information human ... PDE4A(5141)	Gene Information human ... PDE4A(5141)
Quality Level 200	Quality Level 100	Quality Level -	Quality Level -

Application

Zardaverine has been used as a phosphodiesterase inhibitor:

to study its effects on human colonic epithelial cells[1]
to study its effects on junctional proteins in Sertoli cells[2]
to study its effects on phosphodiesterase 3 A (PDE3A) expression in various tumor cells[3]

Biochem/physiol Actions

Selective inhibitor of phosphodiesterase III/IV (PDE3/4).

Zardaverine is a derivative of pyridazinone.[4] It shows anti-tumor and anti-proliferative activity in varied cell lines. Zardaverine possesses broncho-dilatory activity and exhibits therapeutic effects against asthma.[3]

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

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Protection by phosphodiesterase inhibitors against endotoxin-induced liver injury in galactosamine-sensitized mice.

W Fischer et al.

Biochemical pharmacology, 45(12), 2399-2404 (1993-06-22)

Phosphodiesterase inhibitors were used as a tool to manipulate cellular nucleotide levels in vitro and in vivo. The lipopolysaccharide (LPS)-induced release of tumor necrosis factor alpha (TNF-alpha) from mouse peritoneal macrophages was inhibited by prostaglandin E2 with an IC50 of

Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization.

K F Rabe et al.

The American journal of physiology, 264(5 Pt 1), L458-L464 (1993-05-01)

The effects of the nonselective phosphodiesterase (PDE)-inhibitor 3-isobutyl-1-methylxanthine (IBMX) and the selective PDE inhibitors SKF 94120 (type III), rolipram (type IV), zardaverine (type III/IV), and zaprinast (type V) on inherent tone in human airways were investigated. Substantial relaxation was achieved

Low-dose systemic phosphodiesterase inhibitors amplify the pulmonary vasodilatory response to inhaled prostacyclin in experimental pulmonary hypertension.

R T Schermuly et al.

American journal of respiratory and critical care medicine, 160(5 Pt 1), 1500-1506 (1999-11-11)

Inhalation of aerosolized prostaglandin I(2) (PGI(2)) causes selective pulmonary vasodilation, but the effect rapidly levels off after termination of nebulization. In experimental pulmonary hypertension in intact rabbits, provoked by continuous infusion of the stable thromboxane mimetic U46619, the impact of

Bronchodilatory effect of inhaled zardaverine, a phosphodiesterase III and IV inhibitor, in patients with asthma.

T Brunnée et al.

The European respiratory journal, 5(8), 982-985 (1992-09-01)

Zardaverine is a newly developed selective phosphodiesterase III and IV inhibitor. This study investigates the bronchodilatory properties of zardaverine, administered by inhalation. Twelve patients with reversible bronchial obstruction (increase in forced expiratory volume in one second (change FEV1 % predicted)

Bronchodilator and positive inotropic activity of pyridazine compound Zardaverine as a phosphodiesterase isozymes inhibitor

Asif M

Journal of Chemical and Pharmaceutical Sciences , 3(1), 31-34 null

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Zardaverine