C7971

Cilostamide

≥97% (HPLC), PDE3 inhibitor, powder

• Sinónimos: 6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one, OPC 3689
• Fórmula empírica (notación de Hill): C₂₀H₂₆N₂O₃
• Número CAS: 68550-75-4
• Peso molecular: 342.43
• UNSPSC Code: 12352202
• PubChem Substance ID: 24278337
• NACRES: NA.77
• MDL number: MFCD00673958

Propiedades

• Nombre del producto: Cilostamide, phosphodiesterase inhibitor
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• solubility: DMSO: 20 mg/mL, clear, colorless to faintly yellow
• SMILES string: CN(C1CCCCC1)C(=O)CCCOc2ccc3NC(=O)C=Cc3c2
• InChI: 1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
• InChI key: UIAYVIIHMORPSJ-UHFFFAOYSA-N
• Gene Information: human ... PDE3A(5139), PDE3B(5140), PDE5A(8654), PDE7A(5150) ; rat ... Pde2a(81743), Pde4a(25638)

Descripción

Biochem/physiol Actions

Selective cGMP-inhibited phosphodiesterase inhibitor (PDE3); IC₅₀ = 70 ± 9 nM.

Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC₅₀ = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.

PDE3 catalyzes the phosphodiester bond hydrolysis, observed in secondory messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Inhibitors of PDE3 are generally inotropic and vasodilatory. They are being recognized for its use in treating heart failures. Cilostamide is known to delay meiotic progression.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)