U4885

UNC0638 hydrate

≥98% (HPLC)

• Sinónimos: 2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy) quinazolin-4-amine
• Fórmula empírica (notación de Hill): C₃₀H₄₇N₅O₂ · xH₂O
• Número de CAS: 1255517-77-1
• Peso molecular: 509.73 (anhydrous basis)
• Número MDL: MFCD17215972
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329827633
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: solid
• condiciones de almacenamiento: protect from light
• color: off-white
• solubilidad: DMSO: >10 mg/mL
• temp. de almacenamiento: −20°C
• cadena SMILES: O.COc1cc2c(NC3CCN(CC3)C(C)C)nc(nc2cc1OCCCN4CCCC4)C5CCCCC5
• InChI: 1S/C30H47N5O2.H2O/c1-22(2)35-17-12-24(13-18-35)31-30-25-20-27(36-3)28(37-19-9-16-34-14-7-8-15-34)21-26(25)32-29(33-30)23-10-5-4-6-11-23;/h20-24H,4-19H2,1-3H3,(H,31,32,33);1H2
• Clave InChI: LLJGACAJGYXBTL-UHFFFAOYSA-N

Descripción

Descripción general

UNC0638 enhances the E-cadherin expression in gemcitabine-resistant cell line (PANC-1-R).[1]

Aplicación

UNC0638 has been used to block G9a (a lysine methyltransferase) function in C2C12 cells[2]. UNC0638 has also been reported to decrease H3K9 dimethylation (H3K9me2) levels and inhibit cell death in hair cells[3].

UNC0638 hydrate has been used:

• in fractionation and isolation of human blood cells and cell nuclei[4]
• in the analysis of human immunodeficiency virus (HIV) reactivation in latently infected cell line[5]
• to determine the effect of G9a and its enzymatic activity on cisplatin resistance[6]

Acciones bioquímicas o fisiológicas

Histone methyltransferase inhibitor (HMT); G9a/GLP selective methyltransferase chemical probe.

UNC0638 hydrate is a histone methyltransferase (HMT) inhibitor. UNC0638 shows selectivity for G9a (EHMT2) and GLP (EHMT1) methyltransferases, which catalyze the methylation of lysine 9 of histone 3 (H3K9) as well as other non-histone substrates. For full characterization details, please visit the UNC0638 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Características y beneficios

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

UNC0638 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

Otras notas

UNC0638 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the UNC0638 probe summary on the Chemical Probes Portal website.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H300,H413
• Consejos de prudencia: P264 - P270 - P273 - P301 + P310 - P405 - P501
• Clasificaciones de peligro: Acute Tox. 2 Oral - Aquatic Chronic 4
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable