SML1464

SMBA1

≥98% (HPLC)

• Sinónimos: 2-[(2-Nitro-9H-fluoren-9-ylidene)methyl]-phenol, 2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol
• Fórmula empírica (notación de Hill): C₂₀H₁₃NO₃
• Número CAS: 906440-37-7
• Peso molecular: 315.32
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825898
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: OC(C=CC=C1)=C1/C=C2C(C=CC=C3)=C3C4=C\2C=C([N+]([O-])=O)C=C4
• InChI: 1S/C20H13NO3/c22-20-8-4-1-5-13(20)11-18-16-7-3-2-6-15(16)17-10-9-14(21(23)24)12-19(17)18/h1-12,22H/b18-11+
• InChI key: PEYKRJBXACUOOB-WOJGMQOQSA-N

Descripción

Biochem/physiol Actions

SMBA1 is a potent and selective Bax agonist.

Small-molecule Bax agonists 1 (SMBA1) is a potent and selective Bax agonist that binds to Bax, induces conformational change which blocks Bax S184 phosphorylation. SMBA1 induces apoptosis in cancer cells and suppresses lung tumor growth in vivo without significant normal tissue toxicity. SMBA1 does not bind to other B-cell lymphoma 2 (Bcl-2) family members.

SMBA1 is an anti-tumor agent. It exhibits anti-proliferative effects against glioblastoma (GBM) cells.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable