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SML1032

KL001

Name: KL001
Brand: SIGMA

≥98% (HPLC), cryptochrome stabiliser, powder

Sinónimos:

N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide

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Fórmula empírica (notación de Hill):

C₂₁H₂₂N₂O₄S

Número CAS:

309928-48-1

Peso molecular:

398.48

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

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Propiedades

Nombre del producto

KL001, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(N(CC(O)C[n]2c3c(c4c2cccc4)cccc3)Cc1[o]ccc1)C

InChI

1S/C21H22N2O4S/c1-28(25,26)22(15-17-7-6-12-27-17)13-16(24)14-23-20-10-4-2-8-18(20)19-9-3-5-11-21(19)23/h2-12,16,24H,13-15H2,1H3

InChI key

OQAFDLPAPSSOHY-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

KL001 stabilizes cryptochrome (CRY), preventing ubiquitin-dependent degradation.

KL001 stabilizes cryptochrome (CRY), preventing ubiquitin-dependent degradation. CRY proteins are part of a feedback loop, acting as transcription repressors to inhibit CLOCK-BMAL1 components of the circadian clock. KL001 stabilization of CRY proteins results in lengthening of the circadian period, and also inhibited glucagon-induced gluconeogenesis in primary hepatocytes. Other compounds affecting circadian rhythms include Casein kinase I (CKI) inhibitors such as longdaysin (Sigma Prod. No. SML0127) and synthetic ligands for the nuclear receptors REV-ERB such as SR8278 (Sigma Prod. No. S9576), but KL001 appears to be the first small molecule that specifically acts on CRY proteins.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Este artículo	233624	SML3014	SML2999
Sigma-Aldrich SML1032 KL001	Sigma-Aldrich 233624 Cryptocrome Activator, KL001	Sigma-Aldrich SML3014 KL101	Sigma-Aldrich SML2999 KL201
description ≥98% (HPLC)	description The Cryptocrome Activator, KL001 modulates the biological activity of Cryptocrome. This small molecule/inhibitor is primarily used for Biochemicals applications.	description ≥98% (HPLC)	description ≥97% (HPLC)
form powder	form solid	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥97% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 20 mg/mL, clear	solubility DMSO: 50 mg/mL	solubility DMSO: 2 mg/mL, clear	solubility DMSO: 2 mg/mL, clear
color white to beige	color off-white	color white to beige	color white to beige

Pictogramas

GHS07

Palabra de advertencia

Warning

Códigos de peligro

H302

Indicaciones de precaución

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Clase de almacenamiento

11 - Combustible Solids

¿Qué está pasando?

WGK 3

Punto de inflamación (°F)

Not applicable

Punto de inflamación (°C)

Not applicable

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