SML1132

Pep2-8 trifluoroacetate salt

≥95% (HPLC), powder

• Sinónimos: Ac-TVFTSWEEYLDWV-NH₂ trifluoroacetate salt, Ac-TVFTSWEEYLDWV-amide trifluoroacetate salt, Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH₂ trifluoroacetate salt
• Fórmula empírica (notación de Hill): C₈₃H₁₁₀N₁₆O₂₄ · xC₂HF₃O₂
• Peso molecular: 1715.85 (free base basis)
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥95% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: colorless to pale yellow
• shipped in: wet ice
• storage temp.: −20°C

Descripción

Biochem/physiol Actions

Pep2-8 is a potent PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor that selectively binds to PCSK9 and interferes with LDL receptor binding to PCSK9. Pep2-8 restores LDL receptor function and LDL uptake of PCSK9-treated HepG2 cells.

Pep2-8 is a potent PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor.

Pep2-8, a good mimic of epidermal growth factor precursor homology domain A (EGF-A), serves as a competitive inhibitor of low-density lipoprotein (LDL) receptor binding. It can be used as an anchor peptide in phage-display experiments to bind an extension peptide library to the groove site.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable