SML1105

UCF-101

≥98% (HPLC)

• Sinónimos: Dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione
• Fórmula empírica (notación de Hill): C₂₇H₁₇N₃O₅S
• Número de CAS: 313649-08-0
• Peso molecular: 495.51
• Número MDL: MFCD01000361
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825480
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: light orange to dark orange
• solubilidad: DMSO: 5 mg/mL, clear (warmed)
• temp. de almacenamiento: −20°C
• cadena SMILES: S=C(N(C1=CC=CC=C1)C2=O)N(C3=CC=CC=C3)C(C2=CC4=CC=C(C5=CC=CC=C5[N+]([O-])=O)O4)=O
• InChI: 1S/C27H17N3O5S/c31-25-22(17-20-15-16-24(35-20)21-13-7-8-14-23(21)30(33)34)26(32)29(19-11-5-2-6-12-19)27(36)28(25)18-9-3-1-4-10-18/h1-17H
• Clave InChI: NVNSXBXKNMWKEJ-UHFFFAOYSA-N

Descripción

Aplicación

UCF-101 has been used to study its cytoprotective activity in a mouse model of spinal cord injury.[1]

Acciones bioquímicas o fisiológicas

UCF-101 is a selective inhibitor of the pro-apoptotic mitochondrial serine protease Omi/HtrA2, involved in the cellular response to thermal and oxidative stress. Like SMAC/Diablo, Omi/HtrA2 is an inhibitor of IAPs (inhibitor of apoptosis proteins), inhibiting the apoptosis inhibitors, thus resulting in pro-apoptotic activity. In septic rat studies, UCF-101 was found to inhibit apoptosis and have neuroprotective effects on cerebral oxidative injury and cognitive impairment. In aging rats with induced myocardial ischemia/reperfusion (MI/R) injury, UCF-101 treatment decreased XIAP degradation and caspase-3 activity and exerted cardioprotective effects.

UCF-101 is a selective inhibitor of the pro-apoptotic mitochondrial serine protease Omi/HtrA2.

Características y beneficios

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Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable