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Merck
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SML0599

Sigma-Aldrich

DIF-1

≥98% (HPLC)

Sinónimos:

1-(3,5-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-Hexanone

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About This Item

Fórmula empírica (notación de Hill):
C13H16Cl2O4
Número de CAS:
111050-72-7
Peso molecular:
307.17
Código UNSPSC:
12352200
NACRES:
NA.77

Análisis

≥98% (HPLC)

formulario

powder

color

white to beige

solubilidad

DMSO: 20 mg/mL, clear

temp. de almacenamiento

2-8°C

InChI

1S/C13H16Cl2O4/c1-3-4-5-6-7(16)8-11(17)9(14)13(19-2)10(15)12(8)18/h17-18H,3-6H2,1-2H3

Clave InChI

VUDQSRFCCHQIIU-UHFFFAOYSA-N

Acciones bioquímicas o fisiológicas

DIF-1 (differentiation-inducing factor-1) is isolated from a Dictyostelium slime mold, and is used to inhibit proliferation/promote differentiation in various cell lines.
DIF-1 is a cell differentiation inducing factor.
Differentiation-inducing factor-1 (DIF-1) blocks the migration and invasion of cells and decreases the expression of matrix metalloproteinase-2. It prevents the proliferation of cells using glycogen synthase kinase-3 (GSK-3)-dependent mechanism. DIF-1 is more active when compared to DIF-2 in promoting stalk cell differentiation under submerged assay conditions.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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[Low molecular compounds that regulate cell differentiation and chemotaxis in Dictyostelium discoideum].
Yuzuru Kubohara et al.
Seikagaku. The Journal of Japanese Biochemical Society, 82(12), 1132-1137 (2011-02-26)
Jean-Paul Rieu et al.
Cell motility and the cytoskeleton, 66(12), 1073-1086 (2009-08-21)
The collective motion of cells in a biological tissue originates from their individual responses to chemical and mechanical signals. The Dictyostelium slug moves as a collective of up to 100,000 cells with prestalk cells in the anterior 10-30% and prespore
Marie-Françoise Luciani et al.
Autophagy, 7(5), 501-508 (2011-02-09)
We investigated the role of Atg1 in autophagic cell death (ACD) in a Dictyostelium monolayer model. The model is especially propitious, not only because of genetic tractability and absence of apoptosis machinery, but also because induction of ACD requires two
Christopher S Neumann et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(13), 5798-5803 (2010-03-17)
Differentiation-inducing factor 1 (DIF-1) is a polyketide-derived morphogen which drives stalk cell formation in the developmental cycle of Dictyostelium discoideum. Previous experiments demonstrated that the biosynthetic pathway proceeds via dichlorination of the precursor molecule THPH, but the enzyme responsible for
Haruhisa Kikuchi et al.
Biochemical and biophysical research communications, 377(3), 1012-1017 (2008-11-04)
The differentiation-inducing factor-1 (DIF-1) is a lipophilic signal molecule (chlorinated alkylphenone) that induces stalk cell differentiation in the cellular slime mold Dictyostelium discoideum. In addition, DIF-1 and its derivatives have been shown to possess anti-leukemic activity and glucose consumption-promoting activity
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