SML0560

BRACO19 hydrochloride

≥96% (HPLC), powder, telomerase inhibitor

• Sinónimos: N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) hydrochloride
• Fórmula empírica (notación de Hill): C₃₅H₄₃N₇O₂ · xHCl
• Número de CAS: 1177798-88-7
• Peso molecular: 593.76 (free base basis)
• Número MDL: MFCD23380200
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825553
• NACRES: NA.77

Propiedades

• Nombre del producto: BRACO19 hydrochloride, ≥96% (HPLC)
• Nivel de calidad: 100
• Ensayo: ≥96% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated
• color: yellow to brown
• solubilidad: H₂O: 5 mg/mL, clear
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Cl.Cl.Cl.CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc5cc(NC(=O)CCN6CCCC6)ccc25)cc1
• InChI: 1S/C35H43N7O2.3ClH/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42;;;/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39);3*1H
• Clave InChI: MJAPNWJRLLDPAB-UHFFFAOYSA-N

Descripción

Aplicación

BRACO19 hydrochloride has been used to study the role of antiviral activity of G4-stabilizing agents in cells infected with latent human immunodeficiency virus -1 (HIV-1).[1]

Acciones bioquímicas o fisiológicas

BRACO19 is a telomerase inhibitor that stabilizes G-quadruplexes, targeting telomeric G-quadruplexes, inducing DNA damage and cell-cycle arrest.

BRACO19 stabilizes G-quadruplexes; telomerase inhibitor.

Telomerase is associated with tumor progression and is highly expressed in a number of tumors. BRACO19 is known to prevent the capping and catalytic action of telomerase and thus, might serve as an effective therapeutic approach for cancer treatment.[2] BRACO19 establishes antiviral activity against HIV (human immunodeficiency virus).[3]

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H301
• Consejos de prudencia: P264 - P270 - P301 + P310 - P405 - P501
• Clasificaciones de peligro: Acute Tox. 3 Oral
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable