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Acerca de este artículo
Fórmula empírica (notación de Hill):
C21H30O6
Número CAS:
Peso molecular:
378.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Saltar a
Servicio técnico
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Permítanos ayudarleassay
≥98% (HPLC)
form
powder
color
red to orange
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
SMILES string
CCCCCCCCC\C(=C/C1=C(C)C(=O)C(OC)=C(OC)C1=O)C(O)=O
InChI
1S/C21H30O6/c1-5-6-7-8-9-10-11-12-15(21(24)25)13-16-14(2)17(22)19(26-3)20(27-4)18(16)23/h13H,5-12H2,1-4H3,(H,24,25)/b15-13+
InChI key
AALSSIXXBDPENJ-FYWRMAATSA-N
Categorías relacionadas
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Este artículo | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: >20 mg/mL | solubility H2O: <2 mg/mL, DMSO: >20 mg/mL | solubility DMSO: ≥10 mg/mL | solubility DMSO: 10 mg/mL, clear |
| color red to orange | color yellow | color yellow | color white to beige |
Application
E3330 has been used in the inhibition of endothelial cancer cells and apurinic/apyrimidinic endodeoxyribonuclease 1 (APEX1).
Biochem/physiol Actions
E3330 is a specific inhibitor of AP endonuclease 1 redox domain. E3330 inhibits APE-1 regulation of transcription factors, but does not affect Ape1 DNA repair activity. AP endonuclease 1 (APE1; also known as REF-1) is a multifunctional protein with dual functions in DNA repair and redox regulation of transcription factors. It is involved in apurinic/apyrimidinic endonuclease DNA base excision repair activity, in proofreading exonuclease activity, and in modulating DNA binding activity of several transcription factors including NF-κB, Egr-1, p53, AP-1, CREB, HIF-α, and members of the Pax family. APE1 is overexpressed in several human cancers, and disruption of APE1 function has detrimental effects on cancer cell viability. E3330 significantly reduces the growth of human pancreatic cancer cells in vitro and inhibits pancreatic cancer cell migration.
E3330 is a specific inhibitor of AP endonuclease 1 redox domain; inhibits APE-1 regulation of transcription factors, but does not affect Ape1 DNA repair activity.
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 4
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| E8534-5MG | 04061833608784 |
| E8534-25MG | 04061832722344 |
Filtros activos
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