SML0120

Perhexiline maleate salt

≥98% (HPLC), CPT-1 inhibitor, powder

• Sinónimos: 2-(2,2-Dicyclohexylethyl)piperidine
• Fórmula empírica (notación de Hill): C₁₉H₃₅N · C₄H₄O₄
• Número CAS: 6724-53-4
• Peso molecular: 393.56
• NACRES: NA.25
• PubChem Substance ID: 329825171
• UNSPSC Code: 12352200
• EC Number: 229-775-5
• MDL number: MFCD00057329
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: Perhexiline maleate salt, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥5 mg/mL
• storage temp.: 2-8°C
• SMILES string: OC(=O)\C=C/C(O)=O.C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3
• InChI: 1S/C19H35N.C4H4O4/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18;5-3(6)1-2-4(7)8/h16-20H,1-15H2;1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChI key: JDZOTSLZMQDFLG-BTJKTKAUSA-N
• Gene Information: human ... CPT1B(1375), CPT2(1376), MTOR(2475)

Descripción

General description

Perhexiline maleate regulates coronary vasodilatation and blocks exercise-induced tachycardia. It is used to treat angina pectoris and variant angina. Perhexiline maleate functions as a cardiac metabolic agent. It is associated with peripheral neuropathy, high intracranial pressure with papilledema and proximal myopathy.

Application

Perhexiline maleate salt has been used to block fatty acid oxidation. It has also been used as 5′ adenosine monophosphate-activated protein kinase (AMPK) activator and in worm lifespan assay.

Perhexiline maleate salt has been used as a stock for worm lifespan assay. It has also been used to block fatty acid oxidation.

Biochem/physiol Actions

Anti-anginal metabolic modulator; carnitine palmitoyltransferase inhibitor

Perhexiline maleate is an anti-anginal metabolic modulator. It inhibits the mitochondrial enzyme carnitine palmitoyltransferase CPT-1 and to a lesser extent CPT-2. This causes a shift in myocardial substrate utilisation from long chain fatty acids to carbohydrates, resulting in increased glucose and lactate utilization and increased ATP production for the same O2 consumption as before and consequently increases myocardial efficiency. Perhexiline maleate was also recently found to inhibit the activity of mTORC1.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 2
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable