SCP0224
Prostate Specific Antigen Substrate
≥95% (HPLC), lyophilized
Sinónimos:
KLK3, Kallikrein-related peptidase-3, PSA
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About This Item
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product name
Prostate Specific Antigen Substrate,
Análisis
≥95% (HPLC)
formulario
lyophilized
composición
Peptide Content, ≥75%
condiciones de almacenamiento
protect from light
temp. de almacenamiento
−20°C
Amino Acid Sequence
Mu-His-Ser-Ser-Lys-Leu-Gln-AMC
Descripción general
Prostate specific antigen (PSA) is a kallikrein-related serine peptidase that belongs to the chymotrypsin subfamily serine protease. It was originally found in human semen. PSA is also detected in serum correlated to benign and metastatic disease.
Aplicación
Prostate Specific Antigen Substrate has been used to assay recombinant severe acute respiratory syndrome coronavirus-2 viral 3-chymotrypsin-like cysteine protease (SARS-CoV-2 3CLpro).
Acciones bioquímicas o fisiológicas
Prostate specific antigen (PSA). It exhibits chymotrypsin-like activity. PSA is the most abundant protease found in the prostate and secreted into the seminal fluid. It is a useful biomarker for prostate cancer. PSA digests the gel-forming proteins semenogelins I and II in semen. It shows antiangiogenic activity in vitro and in vivo.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Journal of medicinal chemistry, 65(4), 2956-2970 (2021-11-04)
Cathepsin L is a key host cysteine protease utilized by coronaviruses for cell entry and is a promising drug target for novel antivirals against SARS-CoV-2. The marine natural product gallinamide A and several synthetic analogues were identified as potent inhibitors
ACS chemical biology, 16(4), 642-650 (2021-04-01)
Host-cell cysteine proteases play an essential role in the processing of the viral spike protein of SARS coronaviruses. K777, an irreversible, covalent inactivator of cysteine proteases that has recently completed phase 1 clinical trials, reduced SARS-CoV-2 viral infectivity in several
Chemistry & biology, 5(9), 475-488 (1998-09-30)
The serine protease prostate-specific antigen (PSA) is a useful clinical marker for prostatic malignancy. PSA is a member of the kallikrein subgroup of the (chymo)trypsin serine protease family, but differs from the prototypical member of this subgroup, tissue kallikrein, in
Blocking serine protease activity prevents semenogelin degradation leading to hyperviscous semen in humans.
Biology of reproduction, 106, 879-887 (2023)
bioRxiv : the preprint server for biology (2021-01-06)
The emergence of SARS-CoV-2 in late 2019, and the subsequent COVID-19 pandemic, has led to substantial mortality, together with mass global disruption. There is an urgent need for novel antiviral drugs for therapeutic or prophylactic application. Cathepsin L is a
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