SBR00017

Puromycin aminonucleoside Ready Made Solution

10 mg/mL in water

• Sinónimos: 3′-Amino-3′-deoxy-N⁶,N⁶-dimethyladenosine
• Fórmula empírica (notación de Hill): C₁₂H₁₈N₆O₃
• Número de CAS: 58-60-6
• Peso molecular: 294.31
• Código UNSPSC: 51281912
• NACRES: NA.85

Propiedades

• Análisis: ≥98%
• Nivel de calidad: 200
• formulario: liquid
• concentración: 10 mg/mL in water
• espectro de actividad antibiótica: Gram-positive bacteria; neoplastics; parasites
• Modo de acción: protein synthesis | interferes
• temp. de almacenamiento: 2-8°C
• cadena SMILES: N[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N(C)C)=NC=N3)O[C@@H]1CO
• InChI: 1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3
• Clave InChI: RYSMHWILUNYBFW-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

Puromycin aminonucleoside is an aminonucleoside derivative of the known antibiotic puromycin. Puromycin aminonucleoside has been used in nephrology research, studying focal and segmental glomerulosclerosis, and in the induction of nephrosis in rats. Rats with puromycin aminonucleoside-induced nephrotic syndrome were used to study the excretion of sodium and NO_x metabolites.

Puromycin aminonucleoside has also been used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability. A puromycin aminonucleoside nephrosis model of rat glomerular disease was also used to study the role of the neuron-specific ubiquitin C-terminal hydrolase protein gene product 9.5 (PGP 9.5).

Nota de preparación

Puromycin aminonucleoside solution is provided at 10 mg/mL in water and could be further diluted in aqueous buffers to a working concentration of 10 μg/mL (1:1000).

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable