SAE0216
Pepstatin, water soluble
semisynthetic, >=95% pure
Sinónimos:
GKK pepstatyl, Gly-Lys-Lys-pepstatyl, Pepsin inhibitor
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About This Item
Código UNSPSC:
12352202
Productos recomendados
origen biológico
synthetic
Nivel de calidad
formulario
powder
Condiciones de envío
wet ice
temp. de almacenamiento
-10 to -25°C
Descripción general
Pepstatin water soluble is a semisynthetic product derived from microbial Pepstatin A by the addition of the tri-peptide Gly-Lys-Lys-OH. Pepstatin water soluble is a novel product that has the same protease inhibition activity as Pepstatin A, but with increased solubility in water and in physiological media. The increased water solubility provides new options for using this inhibitor in aqueous solutions. Pepstatin water soluble was first described by Austen at al,. The published Ki for inhibition of Pepsin activity is the same as Pepstatin A. While Pepstatin A is only sparingly soluble in water or PBS, the water soluble Pepstatin product is soluble in water and PBS at concentration of 60 mg/ml .
Aplicación
Both Pepstatin A and Water soluble Pepstatin are potent inhibitors of aspartyl proteases. Both of them contain the unusual amino acid statine. Pepstatin A is an inhibitor of acid proteases (aspartyl peptidases). It forms a 1:1 complex with proteases such as pepsin, renin, , cathepsin D , bovine chymosin, and protease B (Aspergillus Niger).4 Solubilized γ-secretase6 and retroviral protease7 are also inhibited by Pepstatin A.
Características y beneficios
- Same protease inhibition activity as Pepstatin A
- Icreased solubility in water and in physiological media
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
J Marciniszyn et al.
Advances in experimental medicine and biology, 95, 199-210 (1977-01-01)
Pepstatin is a low molecular weight, potent inhibitor specific for acid proteases with a Ki value of about 10(-10)M for pepsin. The chemical structure of pepstatin is essentially a hexapeptide which contains two residues of an unusual amino acid, 4-amino-3-hydroxy-6-methylheptanoic
Solid-phase synthesis of a soluble pepstatin derivative suitable for therapeutic use.
B M Austen et al.
Bioscience reports, 2(6), 427-432 (1982-06-01)
K Takahashi et al.
Journal of biochemistry, 80(3), 497-506 (1976-09-01)
Comparative studies have been made on the effects of diazoacetyl-DL-norleucine methyl ester (DAN), 1,2-epoxy-3-(p-nitrophenoxy)propane (EPNP) and pepstatin on acid proteases, including those from Acrocylindrium sp., Aspergillus niger, Aspergillus saitoi, Mucor pusillus, Paecilomyces varioti, Rhizopus chinensis, and Trametes sanguinea, and also
Structures and activities of protease inhibitors of microbial origin.
H Umezawa
Methods in enzymology, 45, 678-695 (1976-01-01)
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