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SAB4502369

Sigma-Aldrich

Anti-HDAC8 antibody produced in rabbit

affinity isolated antibody

Sinónimos:

FKSG78, G-protein coupled receptor 95, GPR87, GPR95, Probable G-protein coupled receptor 87

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About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen 41 kDa

reactividad de especies

human, rat, mouse

concentración

~1 mg/mL

técnicas

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... HDAC8(55869)

Descripción general

Anti-HDAC8 Antibody detects endogenous levels of total HDAC8 protein.
The HDAC8 (histone deacetylase 8) gene is mapped to human chromosome Xq13.1. The encoded protein belongs to the class 1 histone deacetylase family.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human HDAC8.

Immunogen Range: 5-54

Acciones bioquímicas o fisiológicas

The HDAC8 (histone deacetylase 8) protein is significantly involved in cartilage development and matrix-specific gene transcription by catalyzing histone acetylation. HDAC8 has Zn2+-dependent hydrolase activity that deacetylates the acetyl lysine residues of both histone and non-histone proteins. Deacetylation of structural maintenance of chromosome protein 3(SMC3) by HDAC8 is necessary for recycling of cohesin complex during cell cycle. Mutation in the gene is observed in Cornelia de Lange syndrome which is characterised by mental retardation and facial deformity.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Cloning and characterization of human histone deacetylase 8.
Van den Wyngaert I
Febs Letters, 478(1-2), 77-83 (2000)
Structure-Based Identification of HDAC8 Non-histone Substrates.
Alam N
Structure, 24(3), 458-468 (2016)
Bo Du et al.
The Kaohsiung journal of medical sciences, 36(11), 904-910 (2020-07-10)
Alcoholic hepatitis (AH) is identified as an inflammatory syndrome with high morbidity and mortality as a result of severe hepatocellular dysfunction and liver injury. Accumulated studies indicated that miRNAs are involved in AH. The potential effect of miR-451a in AH
MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation.
Chen W
Biochimica et Biophysica Acta, 1863(12), 2881-2891 (2016)
Structural aspects of HDAC8 mechanism and dysfunction in Cornelia de Lange syndrome spectrum disorders.
Deardorff MA
Protein Science, 25(11), 1965-1976 (2016)

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