SAB4500418
Anti-GPR151 antibody produced in rabbit
affinity isolated antibody
Sinónimos:
G-protein coupled receptor PGR7, GPCR-2037, GPR151, PGR7, Probable G-protein coupled receptor 151
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100 μG
459,00 €
459,00 €
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100 μG
459,00 €
About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
459,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Productos recomendados
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
mol peso
antigen 46 kDa
reactividad de especies
rat, human, mouse
concentración
~1 mg/mL
técnicas
ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
Nº de acceso NCBI
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... GPR151(134391)
Categorías relacionadas
Descripción general
G protein-coupled receptor 151 (GPR151) is encoded by the gene mapped to human chromosome 5. It belongs to the A type of G protein-coupled receptor (GPCR) family and it shows homology with galanin receptor 2 and 3. In mice, GPR151 transcript is highly and specifically expressed in habenular neurons.
Inmunógeno
The antiserum was produced against synthesized peptide derived from human GPR151.
Immunogen Range: 370-419
Immunogen Range: 370-419
Aplicación
Anti-GPR151, C-Terminal antibody produced in rabbit has been used for Western blotting.
Acciones bioquímicas o fisiológicas
G protein-coupled receptor 151 (GPR151) is a highly conserved protein, and acts as a potential target for psychiatric drug development, due to its expression in habenular neurons which may be critically involved in the pathophysiology of psychiatric disorders such as addiction and depression. Experimental studies reveal that GPR151 might play a neuroprotective and/or pro-regenerative role in the dorsal root ganglion (DRG) after nerve injury.
Características y beneficios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forma física
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
nwg
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Certificados de análisis (COA)
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Yuxiao Yao et al.
Molecular neurobiology (2023-07-21)
Histamine receptors mediate important physiological processes and take part in the pathophysiology of different brain disorders. Histamine receptor 1 (HRH1) is involved in the development of neurotransmitter systems, and its role in neurogenesis has been proposed. Altered HRH1 binding and
Conserved expression of the GPR151 receptor in habenular axonal projections of vertebrates.
Broms J, et al.
The Journal of Comparative Neurology, 523(3), 359-380 (2015)
Nisa Roy et al.
Scientific reports, 11(1), 5549-5549 (2021-03-12)
G-protein coupled receptor 139 (GPR139) is an evolutionarily conserved orphan receptor, predominantly expressing in the habenula of vertebrate species. The habenula has recently been implicated in aversive response and its associated learning. Here, we tested the hypothesis that GPR139 signalling
Targeted disruption of the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain.
Holmes FE, et al.
Molecular and Cellular Neurosciences, 78, 35-40 (2017)
Jonas Broms et al.
The Journal of comparative neurology, 525(15), 3227-3250 (2017-06-29)
GPR151 is a G-protein coupled receptor for which the endogenous ligand remains unknown. In the nervous system of vertebrates, its expression is enriched in specific diencephalic structures, where the highest levels are observed in the habenular area. The habenula has
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