SAB3500816

Anti-CMPK2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: predicted mol wt 49 kDa
• reactividad de especies: mouse, rat, human
• técnicas: ELISA: suitable; immunofluorescence: suitable; western blot: suitable
• Nº de acceso UniProt: Q5EBM0
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... CMPK2(129607)

Descripción

Descripción general

Cytidine/uridine monophosphate kinase 2 (CMPK2) is expressed in mitochondria. The protein Cmpk2 is similar to thymidylate kinase than to cytosolic Cmpk1. Cmpk2 has thymidylate kinase domain and the C-terminal domain contains all the consensus motifs: P-loop (ATP/ GTP binding motif A), LID (domain in lipase) domain, adenine-base binding loop, catalytic site, and potential substrate binding site. In human chromosome, the gene is localized on 2p25.2.

Acciones bioquímicas o fisiológicas

Cmpk2 utilizes ATP (adenosine triphosphate) as phosphate donor to phosphorylate dUMP (deoxyuridine monophosphate), dCMP (deoxycytidine monophosphate), CMP (cytosine monophosphate), and UMP (uridine monophosphate). The order of substrate specificity for Cmpk2 is UMP, the highest, followed by dCMP, CMP and UMP. Cmpk2 also phosphorylates monophosphate nucleoside analogs ddC (zalcitabine), dFdC (gemcitabine), araC (vidarabine), BVDU (brivudine), and FdUrd (fluorodeoxyuridine). Cmpk2 expression is found in leukemic cells like chronic myelogenous leukemia K-562 and lymphoblastic leukemia MOLT-4, implicates its pathophysiology. The catalytic activity of Cmpk2 is similar to human adenylate kinase 9.

Características y beneficios

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Ligadura / enlace

The action of this antibody can be blocked using blocking peptide SBP3500816.

Forma física

Supplied at 1 mg/mL in PBS with 0.02% sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable