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S3147

Sigma-Aldrich

5-Sulfosalicylic acid dihydrate

suitable for electrophoresis, ≥99%

Sinónimos:

2-Hydroxy-5-sulfobenzoic acid

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About This Item

Fórmula lineal:
HO3SC6H3-2-(OH)CO2H·2H2O
Número de CAS:
5965-83-3
Peso molecular:
254.21
Beilstein:
650741
Número CE:
202-555-6
Número MDL:
MFCD00149540
Código UNSPSC:
41105319
ID de la sustancia en PubChem:
24899547
NACRES:
NB.22

Análisis

≥99%

formulario

powder or crystals

técnicas

electrophoresis: suitable

impurezas

≤0.02% Insoluble matter
≤0.05% Salicylic Acid

mp

105-110 °C (lit.)

solubilidad

water: soluble 100 mg/mL, clear, colorless

trazas de anión

chloride (Cl-): ≤0.001%
sulfate (SO42-): ≤0.035%

trazas de catión

Fe: ≤0.001%
heavy metals (as Pb): ≤0.002%

cadena SMILES

[H]O[H].[H]O[H].OC(=O)c1cc(ccc1O)S(O)(=O)=O

InChI

1S/C7H6O6S.2H2O/c8-6-2-1-4(14(11,12)13)3-5(6)7(9)10;;/h1-3,8H,(H,9,10)(H,11,12,13);2*1H2

Clave InChI

BHDKTFQBRFWJKR-UHFFFAOYSA-N

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Descripción general

5-Sulfosalicylic acid is a strong acid capable of protonating water. It forms a new theophylline complex, which was investigated by X-ray photoelectron spectroscopy (XPS). It forms 1:1 proton-transfer compounds with the ortho-substituted monocyclic heteroaromatic Lewis bases. Their crystal structures have been studied.

Aplicación

5-Sulfosalicylic acid (3.5%) in 12% trichloroacetic acid is commonly used as a fixing solution for proteins in agarose and polyacrylamide gels.
5-Sulfosalicylic acid dihydrate may be employed for the quantification of doxorubicin derived from PEGylated liposomal doxorubicin (Doxil) and its major metabolite in human plasma by HPLC. It may be used in the preparation of poly[[tris(di-2-pyridylamine)tris([μ]-5-sulfonatosalicylato)tricopper(II)] trihydrate].

Nota de análisis

Tested for use in fixing solutions for PAGE, SDS-PAGE and IEF.

Pictogramas

Corrosion
GHS05

Palabra de señalización

Danger

Frases de peligro

H314

Clasificaciones de peligro

Eye Dam. 1 - Skin Corr. 1B

Código de clase de almacenamiento

8A - Combustible corrosive hazardous materials

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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David L Chin et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 779(2), 259-269 (2002-10-04)
A high-performance liquid chromatographic method was developed for the quantification of doxorubicin derived from PEGylated liposomal doxorubicin (Doxil) and its major metabolite in human plasma. This method utilizes Triton X-100 to disperse the liposome, followed by a protein precipitation step
Joanna S Stevens et al.
The journal of physical chemistry. B, 114(44), 13961-13969 (2010-10-22)
Recent studies suggested that X-ray photoelectron spectroscopy (XPS) sensitively determines the protonation state of nitrogen functional groups in the solid state, providing a means for distinguishing between co-crystals and salts of organic compounds. Here we describe how a new theophylline
Hui Wang et al.
Frontiers in physiology, 11, 655-655 (2020-07-01)
Serotonin (5-HT), a monoaminergic neurotransmitter, involves in the regulation of many physiological functions. In the present study, the effects of 5-hydroxytryptophan (5-HTP), the precursor of 5-HT, on lipid metabolism and intestinal immune function in broiler chickens were investigated in chickens.
Megan A Dickson et al.
Reproductive biology and endocrinology : RB&E, 18(1), 49-49 (2020-05-16)
Cigarette smokers have a reduced risk of developing preeclampsia, possibly attributed to an increase in carbon monoxide (CO) levels. Carbon monoxide is a gasotransmitter that has been implicated in maintaining vascular tone, increasing angiogenesis, and reducing inflammation and apoptosis at
Hydrogen bonding in proton-transfer compounds of 5-sulfosalicylic acid with ortho-substituted monocyclic heteroaromatic Lewis bases.
Smith G, et al.
Journal of Chemical Crystallography, 36(12), 841-849 (2006)
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