R1656
RAF1 (EE) (306-end), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinónimos:
CMD1NN, NS5, RAF proto-oncogene serine/threonine-protein kinase, cRaf
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Seleccione un Tamaño
10 μG
510,00 €
510,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Solicitar un pedido a granel
Seleccione un Tamaño
Cambiar Vistas
10 μG
510,00 €
About This Item
Código UNSPSC:
12352200
NACRES:
NA.32
510,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Solicitar un pedido a granel
Productos recomendados
origen biológico
fermentation/recombinant
Nivel de calidad
recombinante
expressed in baculovirus infected Sf9 cells
Línea del producto
PRECISIO® Kinase
Ensayo
≥70% (SDS-PAGE)
Formulario
buffered aqueous glycerol solution
actividad específica
5100-6900 nmol/min·mg
mol peso
~63 kDa
fabricante / nombre comercial
Precision
técnicas
cell based assay: suitable
solubilidad
water: soluble
Nº de acceso Protein ID
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
Información sobre el gen
human ... RAF1(5894)
Descripción general
Research area: Cell Signaling
Rapidly Accelerated Fibrosarcoma (RAF) belongs to receptor tyrosine kinase (RTK) family. RAF exists as three isoforms A, B and C-RAF or RAF-1. [1] RAF1 links Ras family members with mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling cascade.[2] The RAF-1 gene is mapped to the human chromosome at 3p25.2.[3]
Rapidly Accelerated Fibrosarcoma (RAF) belongs to receptor tyrosine kinase (RTK) family. RAF exists as three isoforms A, B and C-RAF or RAF-1. [1] RAF1 links Ras family members with mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling cascade.[2] The RAF-1 gene is mapped to the human chromosome at 3p25.2.[3]
Acciones bioquímicas o fisiológicas
Rapidly Accelerated Fibrosarcoma 1(RAF1), a member of MAP kinase kinase kinase (MAP3K) family plays a vital role in cell signaling by directly interacting with GTPases and functions downstream in their signaling pathway.[4] RaF1 is activated by Ras in the presence of growth-promoting signals, leading to the activation of mitogen-activated protein kinase kinase (MEK1/MEK2) and extracellular signal-regulated protein kinases 1 and 2 (ERK1/ERK2) downstream. [5] The activated ERK proteins control gene expression related to cell division, apoptosis, cell differentiation, and cell migration.[4] The gene is mutated or upregulated in prostate and bladder cancer.[5] Also, mutations are associated with Noonan syndrome, which leads to various physical abnormalities like craniofacial dysmorphisms, ocular, and musculoskeletal irregularities, neurocognitive impairment, and cardiac malformations.[4]
Forma física
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Información legal
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Elija entre una de las versiones más recientes:
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Benjamin R Nixon et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(1), 1138-1150 (2018-08-15)
Raf1/c-Raf is a well-characterized serine/threonine-protein kinase that links Ras family members with the MAPK/ERK signaling cascade. We have identified a novel splice isoform of human Raf1 that causes protein truncation and loss of the C-terminal kinase domain (Raf1-tr). We found
Olafur Andri Stefansson et al.
Breast cancer research : BCR, 13(3), 309-309 (2011-06-16)
Members of the Polycomb-group (PcG) family of proteins, including EZH2 (enhancer of zeste homolog 2), are involved in establishing epigenetic silencing of developmental genes in adult and embryonic stem cells, and their deregulation has been implicated in cancer. In a
Raf kinases: function, regulation and role in human cancer
Leicht DT, et al.
Biochimica et Biophysica Acta, 1773(8), 1196-1212 (2007)
Vertical pathway targeting in cancer therapy
Shahbazian D, et al.
Advances in Pharmacology, 65, 1-26 (2012)
RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis
Wong S, et al.
EMBO Molecular Medicine, 15(5), e17078-e17078 (2023)
Filtros activos
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico
