PZ0191

Crizotinib

≥98% (HPLC)

• Sinónimos: (R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine, PF 2341066, PF-02341066, PF02341066, Xalkori
• Fórmula empírica (notación de Hill): C₂₁H₂₂Cl₂FN₅O
• Número de CAS: 877399-52-5
• Peso molecular: 450.34
• Número MDL: MFCD12407409
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329823765
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to tan
• temp. de almacenamiento: room temp
• cadena SMILES: C[C@@H](Oc1cc(cnc1N)-c2cnn(c2)C3CCNCC3)c4c(Cl)ccc(F)c4Cl
• InChI: 1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
• Clave InChI: KTEIFNKAUNYNJU-GFCCVEGCSA-N
• Información sobre el gen: human ... ALK(238) , MET(4233)

Descripción

Aplicación

Crizotinib has been used:

• to investigate its effects on hepatocyte growth factor receptor (c-Met) expression, proliferation and apoptosis[1]
• to block neurotrophic tyrosine kinase receptor type 1 (NTRK1) activity in epithelial cells[2]
• to restore sensitivity to erlotinib[3]

Acciones bioquímicas o fisiológicas

ATP-competitive c-MET / ALK Inhibitor

Crizotinib (PF-02341066) is an ATP-competitive inhibitor of the receptor tyrosine kinases (RTKs) c-Met (hepatocyte growth factor receptor) and anaplastic lymphoma kinase (ALK). Crizotinib is a highly specific inhibitor of c-Met and ALK among > 120 different RTKs surveyed. Crizotinib was approved for treatment of a subtype of nonsmall-cell lung cancer (NSCLC) with ALK fusion mutations.

Características y beneficios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Información legal

Sold for research purposes under agreement from Pfizer Inc.

Información de seguridad

• Pictogramas: GHS08,GHS07,GHS09
• Palabra de señalización: Warning
• Frases de peligro: H317,H319,H341,H400
• Consejos de prudencia: P202 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Clasificaciones de peligro: Aquatic Acute 1 - Eye Irrit. 2 - Muta. 2 - Skin Sens. 1
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable