P4247 Sigma-Aldrich Anti-Potassium Channel Kv1.3 (extracellular)−FITC antibody produced in rabbit is a rabbit polyclonal antibody, so it is a rabbit IgG-type antibody. Since there are no isotypes/subtypes for rabbit polyclonal IgG, the most suitable negative control would be a normal (i.e., non-immune) rabbit IgG that is conjugated to FITC. Unfortunately at this time, we do not offer an antibody such as this; however, we offer normal rabbit IgG that is either unconjugated (which could be conjugated with FITC at the end-user's facility), or conjugated to other fluorophores, e.g., 16-237 Sigma-Aldrich Normal Rabbit IgG, Alexa Fluor® 488 conjugate.
P4247
Anti-Potassium Channel Kv1.3 (extracellular)−FITC antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Sinónimos:
Anti-Kcna3, Anti-Voltage-gated Potassium Channel KV1.3
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50 μL
851,00 €
851,00 €
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50 μL
851,00 €
About This Item
851,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
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origen biológico
rabbit
Nivel de calidad
conjugado
FITC conjugate
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
lyophilized powder
reactividad de especies
rat, human, mouse
técnicas
flow cytometry: 0.5-5 μg/test using Jurkat T-cells
western blot: 1:200-1:500 using rat brain membranes
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... KCNA3(3738)
mouse ... Kcna3(16491)
rat ... Kcna3(29731)
Descripción general
The (K+) channel family has been sub-grouped in to 2 TM, 4 TM and 6 TM (K+) channels based on the number of transmembrane domains. The voltage-gated Potassium or (Kv) channels belong to the 6 TM (K+) channel family and are expressed mainly in hematopoietic cells such as T and B lymphocytes, macrophages and natural killer cells. (Kv)1.3 facilitates cell proliferation and can also regulate the immune system. Genetic alterations in (Kv) 1.3 lead to epilepsy, episodic ataxia/myokymia, and episodic cardiac arrhythmia (the long QT syndrome). Anti-potassium channel (Kv) 1.3 (extracellular)−FITC antibody can be used for western blotting of rat brain membranes. Rabbit anti- potassium channel (Kv) 1.3 (extracellular) antibodies reacts specifically with rat and human (Kv) 1.3.
Inmunógeno
synthetic peptide corresponding to residues 211-224 of human KV1.3. Rat and mouse are 12/14 residues identical.
Aplicación
Anti-potassium channel (Kv) 1.3 (extracellular)−FITC antibody can be used in immunoblotting and flow cytometry.
Forma física
Lyophilized from phosphate buffered saline, pH 7.4, 1% bovine serum albumin, 0.05% sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
13 - Non Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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R S Lewis et al.
Annual review of immunology, 13, 623-653 (1995-01-01)
Over the past decade, a variety of ion channels have been identified and characterized in lymphocytes by use of the patch-clamp technique. This review discusses biophysical and regulatory aspects of lymphocyte potassium and calcium channels with the aim of understanding
Ildiko Szabo et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 37(3), 965-978 (2015-09-24)
Pharmacological inhibition of the potassium channel Kv1.3 has been shown to selectively kill B cells from patients with chronic lymphocytic leukemia (B-CLL). Here we aimed to biophysically characterize and compare Kv1.3 channel activity in B cells isolated either from healthy
George A Gutman et al.
Pharmacological reviews, 55(4), 583-586 (2003-12-06)
This summary article presents an overview of the molecular relationships among the voltage-gated potassium channels and a standard nomenclature for them, which is derived from the IUPHAR Compendium of Voltage-Gated Ion Channels. The complete Compendium, including data tables for each
Gergely Toldi et al.
International immunology, 22(9), 769-774 (2010-07-06)
Cytokine production in activated T lymphocytes of the term neonate is reduced compared with adults. We aimed to characterize the calcium influx kinetics of activated T lymphocytes in the neonate and to test the functionality and expression of Kv1.3 and
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