Product P1867 - Plasmin from human plasma is from an outside supplier and the manufacturing process is considered proprietary. The product is activated with Streptokinase and this enzyme is removed in the final steps of the purification. The product is >95% by SDS PAGE. The product is >3% protein (the exact value will be on the lot specific Certificate of Analysis). This material is lyophilized from 20 mM sodium phosphate (pH 7.4), containing 25 mM Trehalose. The lyophyllization buffer will contribute a significant amount of solids to the product. The product package size is based on protein content.
P1867
Plasmin from human plasma
lyophilized powder, ≥2.0 units/mg protein
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Sinónimos:
Fibrinolysin
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| Talla/SKU | Disponibilidad | Precio |
|---|---|---|
150 μg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 226,00 € |
500 μg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 546,00 € |
750 μg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 757,00 € |
1500 μg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 1460,00 € |
Acerca de este artículo
Número CAS:
UNSPSC Code:
12352204
eCl@ss:
42030239
EC Number:
232-640-3
NACRES:
NA.54
MDL number:
Número CE:
Specific activity:
≥2.0 units/mg protein
226,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Servicio técnico
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Permítanos ayudarleGeneral description
Application
Biochem/physiol Actions
It is inhibited by α 2-antiplasmin and its interaction with fibrin is blocked. It digests the N-terminal region of the cytoplasmic protein αsynuclein preventing its uptake by surrounding cells.
Plasmin exhibits preferential cleavage at the carboxyl side of lysine and arginine residues with higher selectivity than trypsin. Converts polymerized fibrin into soluble products.
pH Optimum: 8.5
pH 7.5: ~40% of maximal activity, pH 9.5: ~50% of maximal activity
Temperature Optimum: 37 °C with rapid inactivation at 56 °C
pH Optimum: 8.5
pH 7.5: ~40% of maximal activity, pH 9.5: ~50% of maximal activity
Temperature Optimum: 37 °C with rapid inactivation at 56 °C
Packaging
Package size based on protein content
Physical form
20 mM NaPO4, pH 7.4, with 25 mM Trehalose
Other Notes
One unit will produce one μmole of p-Nitroanilide from D-Val-Leu-Lys-p-Nitroanilide per minute at pH 7.5 at 37 °C.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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Este artículo | ||
|---|---|---|
| description lyophilized powder, ≥2.0 units/mg protein | description lyophilized powder, 1500-3500 NIH units/mg protein (E1%/280, 18.3), suitable for cell culture | description lyophilized powder, ≥1,000 NIH units/mg protein (E1%/280, 18.3) |
| Gene Information human ... PLG(5340) | Gene Information human ... F2(2147) | Gene Information human ... F2(2147) |
| specific activity ≥2.0 units/mg protein | specific activity 1500-3500 NIH units/mg protein (E1%/280, 18.3) | specific activity ≥1,000 NIH units/mg protein (E1%/280, 18.3) |
| application(s) diagnostic assay manufacturing | application(s) - | application(s) diagnostic assay manufacturing |
| form lyophilized powder | form lyophilized powder | form lyophilized powder |
| UniProt accession no. | UniProt accession no. | UniProt accession no. |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
Clase de almacenamiento
11 - Combustible Solids
Punto de inflamación (°F)
Not applicable
Punto de inflamación (°C)
Not applicable
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Can you provide a method of production for Product P1867 - Plasmin?
1 respuesta-
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Is more information available on the solubility of product P1867 to aid with its application?
1 respuesta-
The solubility of this product is not part of the QC testing; however, according to literature data, it should dissolve at least up to 1 mg/ml in an aqueous solvent. This preparation is recommended to go into water.
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Is the P1867-150UG product in Lys-Plasmin form or Glu-Plasmin form?
1 respuesta-
Both the Glu- and Lys- forms are assumed to be present in the product, as amino-terminal peptides are released from the native Glu-form to the new Lys-form by plasmin in vivo and during purification. No separation of the two forms is performed once purified plasminogen has been converted to plasmin.
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Is there a conversion to International Units (I.U.) for Product P1867, Plasmin from human plasma?
1 respuesta-
Sigma has not evaluated the activity of this enzyme in I.U., nor do we have a conversion factor.
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What is the molecular weight of Product P1867, Plasmin from human plasma?
1 respuesta-
The molecular weight of this dimeric protein was reported to be 75,400 Daltons. Reference is: The Plasma Proteins, Volume 1, 2nd ed., Putnam, F.W., ed., p. 66 (1975).
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Does Product P1867, Plasmin from human plasma, have a recommended retest date?
1 respuesta-
If a product has a recommended retest date this would be on the Certificate of Analysis found at our website. If no recommended retest date is found on the Certificate of Analysis, then the guarantee of quality is one year from the time of delivery for unopened bottles stored at the recommended temperature.
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Can Product P1867, Plasmin from human plasma, be stored?
1 respuesta-
Sigma has not evaluated the solution stability of plasmin solutions.It is best to prepare solutions fresh.
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What is the Department of Transportation shipping information for this product?
1 respuesta-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is Product P1867, Plasmin from human plasma, soluble in?
1 respuesta-
It is soluble in water.
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