N161
NPC-15437 dihydrochloride hydrate
≥97% (NMR), powder
Sinónimos:
(S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide dihydrochloride hydrate
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About This Item
Fórmula empírica (notación de Hill):
C25H50N4O2 · 2HCl · xH2O
Número de CAS:
Peso molecular:
511.61 (anhydrous basis)
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.77
Productos recomendados
Ensayo
≥97% (NMR)
Formulario
powder
condiciones de almacenamiento
desiccated
color
white
solubilidad
H2O: 10 mg/mL, clear
temp. de almacenamiento
2-8°C
cadena SMILES
Cl[H].Cl[H].CCCCCCCCCCCCC(=O)N1CCCCC1CNC(=O)[C@@H](N)CCCCN
InChI
1S/C25H50N4O2.2ClH/c1-2-3-4-5-6-7-8-9-10-11-18-24(30)29-20-15-13-16-22(29)21-28-25(31)23(27)17-12-14-19-26;;/h22-23H,2-21,26-27H2,1H3,(H,28,31);2*1H/t22?,23-;;/m0../s1
Clave InChI
RISSBZWRJRRXTD-OLBPYZPGSA-N
Aplicación
NPC-15437 dihydrochloride hydrate has been used as a protein kinase C (PKC) inhibitor:
- to test its blocking effect on nicotine-seeking behavior in mice in drug-paired cues[1]
- along with cocaine to test its effect on 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity in mice[2]
- to study its effect on PKC signaling in object recognition memory studies[3]
Acciones bioquímicas o fisiológicas
NPC 15437 is also reported to be a P-glycoprotein (Pgp) modulator.[4]
Selective protein kinase C inhibitor.
Características y beneficios
This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Código de clase de almacenamiento
13 - Non Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Ainhoa Plaza-Zabala et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38(9), 1724-1736 (2013-03-23)
Hypocretin/orexin signaling is critically involved in relapse to drug-seeking behaviors. In this study, we investigated the involvement of the hypocretin system in the reinstatement of nicotine-seeking behavior induced by nicotine-associated cues. Pretreatment with the hypocretin receptor-1 antagonist SB334867, but not
NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs.
J P Sullivan et al.
FEBS letters, 285(1), 120-123 (1991-07-08)
We recently demonstrated that 2,6,diamino-N-[( 1-(oxotridecyl)-2-piperidinyl]methyl)-hexanamide (NPC 15437) is a selective inhibitor of PKC interacting at the regulatory domain of the enzyme. To further investigate the interaction of NPC 15437 with PKC we expressed a series of cDNAs encoding mutant
E C Sha et al.
Investigational new drugs, 13(4), 285-294 (1996-01-01)
We assessed the effect of the protein kinase C inhibitor 2,6-diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)hexanami de (NPC 15437) on the action of anthracyclines, epipodophyllotoxins and vinca alkaloids in P-glycoprotein (Pgp)-expressing CH(R)C5 hamster ovary and MCF-7/Adria(R) human breast cancer cells. Flow microfluorimetry revealed that treatment
I Peraile et al.
British journal of pharmacology, 159(1), 201-211 (2009-12-18)
3,4-Methylenedioxymethamphetamine (MDMA) and cocaine are two widely abused psychostimulant drugs targeting the dopamine transporter (DAT). DAT availability regulates dopamine neurotransmission and uptake of MDMA-derived neurotoxic metabolites. We aimed to determine the effect of cocaine pre-exposure on the acute and long-term
J P Sullivan et al.
Molecular pharmacology, 41(1), 38-44 (1992-01-01)
NPC 15437 is a prototype member of a new class of synthetically derived protein kinase C (PKC) inhibitors. PKC activity and binding of phorbol ester to the enzyme were inhibited by NPC 15437, with IC50 values of 19 +/- 2
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