L8912

L-Leucine

98.5-101.0%, suitable for cell culture, non-animal source, meets EP, JP, USP testing specifications

• Sinónimos: (S)-Leucine, (S)-2-Amino-4-methylpentanoic acid
• Fórmula lineal: (CH₃)₂CHCH₂CH(NH₂)CO₂H
• Número de CAS: 61-90-5
• Peso molecular: 131.17
• Beilstein: 1721722
• Número CE: 200-522-0
• Número MDL: MFCD00002617
• Código UNSPSC: 12352209
• eCl@ss: 32160406
• ID de la sustancia en PubChem: 24896510
• NACRES: NA.26

Propiedades

• Nombre del producto: L-Leucine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
• origen biológico: non-animal source
• Agency: USP/NF; meets EP testing specifications; meets JP testing specifications; meets USP testing specifications
• Ensayo: 98.5-101.0%
• Formulario: powder
• actividad óptica: [α]20/D 14.9 to 16.0°, c = 4 in 6 M HCl; [α]25/D 14.9 to 17.3 °, c = 4 in 6 M HCl
• calidad: meets EP, JP, USP testing specifications
• técnicas: cell culture | mammalian: suitable
• impurezas: endotoxin, tested
• color: white
• mp: >300 °C (lit.)
• solubilidad: 1 M HCl: 50 mg/mL
• trazas de catión: As: ≤1 ppm; Fe: ≤10 ppm; NH₄⁺: <0.02%; heavy metals: ≤10 ppm
• aplicaciones: peptide synthesis; pharmaceutical (small molecule)
• grupo funcional: amine; carboxylic acid
• temp. de almacenamiento: room temp
• cadena SMILES: CC(C)C[C@H](N)C(O)=O
• InChI: 1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
• Clave InChI: ROHFNLRQFUQHCH-YFKPBYRVSA-N

Descripción

Descripción general

Leucine is a non-glucogenic, and essential amino acid. It is a branched-chain amino acid that is a structural component of proteins.[1]

Aplicación

L-Leucine has been used:

• as a hypertrophic agent to monitor its effects on myotubes.[2]
• as a component of PMG media for culturing yeast.[3]
• in myotube protein synthesis analysis in skeletal muscle cells.[4]
• to study its effects on hepatic lipid metabolism.[5]

Acciones bioquímicas o fisiológicas

Leucine plays a role in intracellular signaling, gene transcription, and translation. It promotes the synthesis of protein by activating the mammalian target of the rapamycin (mTOR) signaling pathway in placental cells, skeletal muscles, and adipose tissue.[6] Leucine inhibits protein degradation and promotes mitochondrial biogenesis, glucose metabolism, and fatty acid oxidation to provide energy for protein synthesis.[1]

Otras notas

For additional information on our range of Biochemicals, please complete this form.

The product is intended for laboratory use only, and it is not suitable for drug, household, or other purposes.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)