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L4420

Sigma-Aldrich

LY-367385 hydrochloride

≥98% (HPLC)

Sinónimos:

(S)-(+)-a-amino-4-carboxy-2-methylbenzeneacetic acid

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About This Item

Fórmula empírica (notación de Hill):
C10H11NO4 ·HCl
Número de CAS:
198419-91-9
Peso molecular:
245.66
Número MDL:
MFCD02262124
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329817409
NACRES:
NA.77

Análisis

≥98% (HPLC)

formulario

powder

condiciones de almacenamiento

desiccated

color

white to off-white

solubilidad

H2O: >10 mg/mL

emisor

Eli Lilly

temp. de almacenamiento

room temp

cadena SMILES

Cc1cc(ccc1[C@H](N)C(O)=O)C(O)=O

InChI

1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15)/t8-/m0/s1

Clave InChI

SGIKDIUCJAUSRD-QMMMGPOBSA-N

Aplicación

LY-367385 hydrochloride has been used as a non-N-methyl-D-aspartate (NMDA) glutamate receptor blocker in neuronal stimulation experiment.

Acciones bioquímicas o fisiológicas

LY-367385 hydrochloride has an ability to inhibit induction of long-term potentiation (LTP).
LY-367385 is a selective metabotropic glutamate 1a receptor (mGlu1a) antagonist.

Características y beneficios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Modulatory action of metabotropic glutamate receptor (mGluR) 5 on mGluR1 function in striatal cholinergic interneurons
Bonsi P, et al.
Neuropharmacology, 49(5), 104-113 (2005)
Synaptic activity induces input-specific rearrangements in a targeted synaptic protein interaction network
Lautz JD, et al.
Journal of Neurochemistry, 146(5), 540-559 (2018)
D Y Sakae et al.
Molecular psychiatry, 20(11), 1448-1459 (2015-08-05)
Tonically active cholinergic interneurons (TANs) from the nucleus accumbens (NAc) are centrally involved in reward behavior. TANs express a vesicular glutamate transporter referred to as VGLUT3 and thus use both acetylcholine and glutamate as neurotransmitters. The respective roles of each
Miseon Kang et al.
Scientific reports, 10(1), 17921-17921 (2020-10-23)
Abnormally increased neuronal activity in the lateral habenula (LHb) is closely associated with depressive-like behavior. Despite the emphasis on the pathological importance of NMDA receptor (NMDAR)-dependent long-term depression (LTD) and the involvement of calcium permeable AMPA receptor (CP-AMPAR) as major
Michelle Corkrum et al.
Neuron, 105(6), 1036-1047 (2020-01-20)
Dopamine is involved in physiological processes like learning and memory, motor control and reward, and pathological conditions such as Parkinson's disease and addiction. In contrast to the extensive studies on neurons, astrocyte involvement in dopaminergic signaling remains largely unknown. Using
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