L4021
Prolactin human
recombinant, expressed in E. coli, lyophilized powder, BioReagent, suitable for cell culture, >97% (SDS-PAGE)
Sinónimos:
hPRL, LTH, Lactogenic Hormone, Luteotropic Hormone, PRL
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50 μG
365,00 €
365,00 €
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50 μG
365,00 €
About This Item
origen biológico:
Escherichia coli
Formulario:
lyophilized powder
Ensayo:
>97% (SDS-PAGE)
365,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Solicitar un pedido a granel
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origen biológico
Escherichia coli
Nivel de calidad
recombinante
expressed in E. coli
descripción
200 amino acid residue methionyl form of mature, recombinant human prolactin (amino acid residues 29-227).
Línea del producto
BioReagent
Ensayo
>97% (SDS-PAGE)
Formulario
lyophilized powder
potencia
0.030-0.300 ng/mL EC50
mol peso
predicted mol wt ~24 kDa
técnicas
cell culture | mammalian: suitable
impurezas
endotoxin, tested
solubilidad
water: 0.5000 mL, clear, colorless
Nº de acceso UniProt
Condiciones de envío
ambient
temp. de almacenamiento
−20°C
Información sobre el gen
human ... PRL(5617)
Aplicación
Use in cell culture applications to study prolactin regulation of cell signaling and gene expression.
Acciones bioquímicas o fisiológicas
Neuroendocrine hormone; belongs to the cytokine hematopoietic receptor family; induces lactation; inhibits secretion of gonadotropins; release is inhibited by dopamine.
Prolactin is a neuroendocrine hormone. The prolactin receptor is a transmembrane glycoprotein that belongs to the cytokine hematopoietic receptor family. A large number of cells and organs express the receptor, including B cells, T cells, macrophages, monocytes, and neutrophils. Prolactin signal transduction involves the JAK/STAT families and the src kinase family. Induces lactation; inhibits secretion of gonadotropins; release is inhibited by dopamine.
Otras notas
Contains an N-terminal methionine not present in the natural product.
Forma física
Lyophilized from a solution in 10 mM phosphate and 50 mM sodium chloride, pH 8.0.
Reconstitución
It is recommended that sterile 4 mM HCl containing 1 mg/mL bovine serum albumin be added to the vial to prepare a stock solution of no less than 100 μg/mL.
Nota de análisis
The biological activity is assayed by proliferation of the rat lymphoma cell line, Nb2-11.
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Repr. 1B
Código de clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Los clientes también vieron
Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects.
N Ben-Jonathan et al.
Endocrine reviews, 17(6), 639-669 (1996-12-01)
Regulatory action of prolactin on the in vitro growth of CD34+ve human hemopoietic progenitor cells.
G Bellone et al.
Journal of cellular physiology, 163(2), 221-231 (1995-05-01)
The pituitary hormone prolactin (Prl) is known to act as a local regulator of immune cell function, and Prl-binding receptors (Prl-R) have been described to share distinctive features with the members of the newly described cytokine/hemopoietin receptor superfamily. Here we
Julien Auffret et al.
American journal of physiology. Endocrinology and metabolism, 305(10), E1309-E1318 (2013-09-26)
Prolactin (PRL) and placental lactogens stimulate β-cell replication and insulin production in pancreatic islets and insulinoma cells through binding to the PRL receptor (PRLR). However, the contribution of PRLR signaling to β-cell ontogeny and function in perinatal life and the
Gerda de Kuijper et al.
Research in developmental disabilities, 34(9), 2799-2809 (2013-06-25)
Individuals with intellectual disability frequently use antipsychotics for many years. This may have detrimental health effects, including neurological symptoms and metabolic and hormonal dysregulation, the latter possibly affecting bone metabolism. There is large variability in the degree in which antipsychotic
Bibiana Moreno-Carranza et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 305(7), R720-R726 (2013-08-21)
Prolactin (PRL) is a potent liver mitogen and proangiogenic hormone. Here, we used hyperprolactinemic rats and PRL receptor-null mice (PRLR(-/-)) to study the effect of PRL on liver growth and angiogenesis before and after partial hepatectomy (PH). Liver-to-body weight ratio
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