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I2765

Sigma-Aldrich

Ibotenic acid

~95% (TLC), solid, neurotoxin

Sinónimos:

α-Amino-3-hydroxy-5-isoxazoleacetic acid

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About This Item

Fórmula empírica (notación de Hill):
C5H6N2O4
Número de CAS:
2552-55-8
Peso molecular:
158.11
Número MDL:
MFCD00069294
Código UNSPSC:
12352209
ID de la sustancia en PubChem:
24277994
NACRES:
NA.32

product name

Ibotenic acid, ~95%, solid

Análisis

~95%

formulario

solid

color

white

solubilidad

H2O: 1 mg/mL, clear, colorless (with sonication)
0.1 M NaOH: 10.7 mg/mL
0.1 M HCl: 4.7 mg/mL

cadena SMILES

NC(C(O)=O)C1=CC(=O)NO1

InChI

1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)

Clave InChI

IRJCBFDCFXCWGO-UHFFFAOYSA-N

Información sobre el gen

rat ... Grm1(24414) , Grm2(24415)

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Aplicación

Ibotenic acid has been used as a neurontoxin in rats. It has also been used in inducing a primary permanent lesion monkey cortex M1 neurons.
Ibotenic acid has been used to perform surgery in adult male zebra finches (Taeniopygia guttata) to study reversing reinforcement-induced vocal changes.

Acciones bioquímicas o fisiológicas

Ibotenic acid is an analog of glutamate. It is involved in the excitation of cell bodies and destroys the thalamic reticular nucleus (NRT). It induces high calcium influx leading to neuronal injury. Ibotenic acid is used to induce neurodegeneration due to its excitotoxic functionality.
Non-selective agonist with preference for NMDA glutamate receptors; neurotoxin; neuroexcitatory amino acid originally isolated from Amanita species.

Precaución

Hygroscopic

Pictogramas

Skull and crossbones
GHS06

Palabra de señalización

Danger

Frases de peligro

H301

Consejos de prudencia

P301 + P310 + P330

Clasificaciones de peligro

Acute Tox. 3 Oral

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Benjamin M Basile et al.
PLoS biology, 18(6), e3000677-e3000677 (2020-06-13)
A key feature of most social relationships is that we like seeing good things happen to others. Research has implicated the anterior cingulate cortex (ACC) in attaching value to social outcomes. For example, single neurons in macaque ACC selectively code
Anja T Zai et al.
Nature communications, 11(1), 5940-5940 (2020-11-25)
Sensory substitution is a promising therapeutic approach for replacing a missing or diseased sensory organ by translating inaccessible information into another sensory modality. However, many substitution systems are not well accepted by subjects. To explore the effect of sensory substitution
Jiachao Wang et al.
Behavioural brain research, 372, 112037-112037 (2019-06-17)
Our internal models of the world help us to process information rapidly: in general model-based learning is more rapid than model-free learning. However, the cognitive flexibility required to overcome cognitive predispositions can let us down: it is not fully developed
L T Lopes et al.
Acta physiologica (Oxford, England), 211(3), 528-537 (2014-03-13)
Although periaqueductal grey matter activation is known to elicit respiratory and cardiovascular responses, the role of this midbrain area in the compensatory responses to hypoxia is still unknown. To test the participation of the periaqueductal grey matter in cardiorespiratory and
Intrahippocampal administration of ibotenic acid induced cholinergic dysfunction via NR2A/NR2B expression: Implications of resveratrol against Alzheimer disease pathophysiology
Karthick C, et al.
Frontiers in Molecular Neuroscience, 9, 28-28 (2016)
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