G5884

Guanosine 5′-triphosphate lithium salt

~95% (HPLC), powder

• Sinónimos: GTP lithium salt
• Fórmula empírica (notación de Hill): C₁₀H₁₆N₅O₁₄P₃ · xLi⁺
• Número de CAS: 85737-04-8
• Peso molecular: 523.18 (free acid basis)
• Número MDL: MFCD00070012
• Código UNSPSC: 41106305
• ID de la sustancia en PubChem: 24895236
• NACRES: NA.77

Propiedades

• Análisis: ~95% (HPLC)
• formulario: powder
• color: white
• solubilidad: H₂O: 100 mg/mL
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• cadena SMILES: [Li+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1
• InChI: 1S/C10H16N5O14P3.Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
• Clave InChI: WDCLDKGIVWUKSE-GWTDSMLYSA-M

Descripción

Aplicación

Guanosine 5′-triphosphate lithium salt has been used:

• In ribosome activity assay.
• In tubulin isolation and polymerization.
• In the determination of cell viability.

Acciones bioquímicas o fisiológicas

GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.

Guanosine 5′-triphosphate serves as a substrate for guanosine 5′-triphosphate 3′ diphosphate diphosphatase, a hydrolyzing enzyme and guanosine triphosphate guanyltransferase.

Características y beneficios

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Precaución

Stability is much better than sodium salt.

Nota de preparación

Prepared by enzymatic phosphorylation of 5′-GMP.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves