Saltar al contenido
Merck
Todas las fotos(1)

Documentos

F7053

Sigma-Aldrich

Anti-vinculina monoclonal antibody produced in mouse

clone hVIN-1, purified from hybridoma cell culture

Sinónimos:

Monoclonal Anti-Vinculin antibody produced in mouse

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Número MDL:
MFCD00162905
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

mouse

conjugado

FITC conjugate

forma del anticuerpo

purified immunoglobulin

tipo de anticuerpo

primary antibodies

clon

hVIN-1, monoclonal

formulario

buffered aqueous solution

mol peso

antigen 116 kDa

reactividad de especies

frog, chicken, mouse, canine, human, bovine, rat, turkey

condiciones de almacenamiento

protect from light

técnicas

direct immunofluorescence: 1:50 using methanol/acetone fixed cultured bovine MDBK cells

isotipo

IgG1

Nº de acceso UniProt

P18206

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... VCL(7414)
mouse ... Vcl(22330)
rat ... Vcl(305679)

¿Está buscando productos similares? Visita Guía de comparación de productos

Categorías relacionadas

Especificidad

Marca de manera específica la vinculina en los contactos célula-célula y célula-sustrato. Reacciona fuertemente con la vinculina humana. Muestra reactividad cruzada con la metavinculina del músculo liso.

Inmunógeno

vinculina humana purificada del útero.

Aplicación

Monoclonal Anti-Vinculin-FITC antibody is suitable for immunofluorescence staining of fibroblasts cells to study the effects of nanofiber spatial organization on cell behaviors. It is also suitable for direct immunofluorescence at a dilution of 1:50 using methanol/acetone fixed cultured bovine MDBK cells.

Acciones bioquímicas o fisiológicas

Vinculin is a cytoskeletal protein with molecular mass of ~116 kDa. Vinculin is closely associated with adhesive membrane areas, such as focal contacts, podosomes, or intercellular junctions of the zonula adherens type. It acts as a mediator in interactions of integrins and the actin cytoskeleton. It forms a bridge between integrins, receptors for ECM molecules on the cell surface and the F-actin cytoskeleton. It is associated with talin and α-actinin which directly connects with integrins. It has ability to bind α-catenin as well as the vasodilator stimulated phosphoprotein (VASP) in focal contact assembly.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Herramienta de selección de productos.

Producto relacionado

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

E E Weiss et al.
The Journal of cell biology, 141(3), 755-764 (1998-06-13)
In epithelial cells, alpha-, beta-, and gamma-catenin are involved in linking the peripheral microfilament belt to the transmembrane protein E-cadherin. alpha-Catenin exhibits sequence homologies over three regions to vinculin, another adherens junction protein. While vinculin is found in cell-matrix and
Leonel E Rojo et al.
Journal of cosmetic dermatology, 9(3), 185-195 (2010-10-05)
Cell migration, angiogenesis, inflammation, and extracellular matrix remodeling are key events in wound healing. Natural products, including fatty acids (FAs), can accelerate wound healing by modulating the aforementioned events. This study aims to evaluate the effect of lucuma (Pouteria lucuma
A Westmeyer et al.
The EMBO journal, 9(7), 2071-2078 (1990-07-01)
We have analyzed the functional domain structure of vinculin, a protein involved in linking microfilaments to the cytoplasmic face of cell membranes in animal cells. For this purpose, we used several monoclonal antibodies raised against chicken gizzard vinculin whose epitopes
Carol Jurchenko et al.
Biophysical journal, 106(7), 1436-1446 (2014-04-08)
The interplay between chemical and mechanical signals plays an important role in cell biology, and integrin receptors are the primary molecules involved in sensing and transducing external mechanical cues. We used integrin-specific probes in molecular tension fluorescence microscopy to investigate
Mathieu Maalouf et al.
Nanomaterials (Basel, Switzerland), 12(10) (2022-05-29)
Ultrashort pulse lasers have significant advantages over conventional continuous wave and long pulse lasers for the texturing of metallic surfaces, especially for nanoscale surface structure patterning. Furthermore, ultrafast laser beam polarization allows for the precise control of the spatial alignment
Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico