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Merck

F112

(+)-Fenfluramine hydrochloride

serotonin uptake inhibitor, powder

Sinónimos:

(+)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride, Dexfenfluramine hydrochloride

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Fórmula empírica (notación de Hill):
C12H16F3N · HCl
Número CAS:
3239-45-0
Peso molecular:
267.72
NACRES:
NA.77
PubChem Substance ID:
24894746
UNSPSC Code:
12352116
EC Number:
221-806-0
MDL number:
MFCD00069276
Form:
powder
Quality level:
200

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Nombre del producto

(+)-Fenfluramine hydrochloride,

InChI key

ZXKXJHAOUFHNAS-FVGYRXGTSA-N

InChI

1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H/t9-;/m0./s1

SMILES string

Cl[H].CCN[C@@H](C)Cc1cccc(c1)C(F)(F)F

form

powder

drug control

USDEA Schedule IV

color

white to off-white

solubility

H2O: soluble 10 mg/mL

application(s)

forensics and toxicology

storage temp.

room temp

Quality Level

200

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR6(3362), HTR7(3363)

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Este artículo
N3288S9944SML0460
(+)-Fenfluramine hydrochloride

Sigma-Aldrich

F112

(+)-Fenfluramine hydrochloride

(+)-Norfenfluramine hydrochloride ≥98% (HPLC), powder

Sigma-Aldrich

N3288

(+)-Norfenfluramine hydrochloride

Sibutramine hydrochloride monohydrate ≥98% (HPLC), solid

Sigma-Aldrich

S9944

Sibutramine hydrochloride monohydrate

Methylhexanamine hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0460

Methylhexanamine hydrochloride

form

powder

form

powder

form

solid

form

powder

drug control

USDEA Schedule IV

drug control

-

drug control

USDEA Schedule IV

drug control

-

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

2-8°C

storage temp.

room temp

storage temp.

room temp

solubility

H2O: soluble 10 mg/mL

solubility

H2O: >10 mg/mL

solubility

DMSO: >30 mg/mL, H2O: insoluble

solubility

H2O: 5 mg/mL (clear solution)

color

white to off-white

color

white

color

white

color

white to beige

Biochem/physiol Actions

(+)-Fenfluramine is a serotonin uptake inhibitor; anoxexic.
(+)-Fenfluramine is a serotonin uptake inhibitor; anoxexic. (+)-Fenfluramine is neurotoxic on prolonged administration or at high dosage. (+)-Fenfluramine releases serotonin from axon terminals by a nonexocytotic mechanism.

Other Notes

Active isomer

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
0000333406
0000333406
SLBJ7261V
SLBF9148V
075K4714

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Margaret R Maclean et al.
Advances in experimental medicine and biology, 661, 309-322 (2010-03-06)
The serotonin hypothesis of pulmonary arterial hypertension (PAH) arose after an outbreak of PAH in patients taking the anorexigenic drugs aminorex and dexfenfluramine. Both of these drugs are serotonin transporter (SERT) substrates and indirect serotinergic agonists. There is now a
Korneel Rabaey et al.
Current opinion in biotechnology, 22(3), 371-377 (2011-03-01)
The production of biofuels and biochemicals is highly electron intensive. To divert fermentative and respiratory pathways to the product of interest, additional electrons (i.e. reducing power) are often needed. Meanwhile, the past decade has seen the breakthrough of sustainable electricity
Effects of d- and 1-fenfluramine on striatal homovanillic acid concentrations in rats after pharmacological manipulation of brain serotonin.
V Crunelli et al.
Pharmacological research communications, 12(3), 215-223 (1980-03-01)
Nicolas Desbuards et al.
European journal of pharmacology, 602(2-3), 355-363 (2008-12-04)
The anorectic drug, dexfenfluramine has been associated with an increase in the relative risk of developing pulmonary hypertension. 5-hydroxytryptamine (5-HT) is a mitogen for smooth muscle cell, an effect that relies on 5-HT transporter expression and which has been proposed
Dan Jones
Nature reviews. Drug discovery, 7(12), 961-962 (2008-12-02)
A wave of terminations of development programmes for cannabinoid receptor 1 blockers for obesity indicates the demise of a drug class that was once anticipated to yield blockbusters. Nevertheless, lessons learned might help salvage something for future such approaches.
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